J
John Douglas Mcpherson
Researcher at University of California, Davis
Publications - 216
Citations - 73141
John Douglas Mcpherson is an academic researcher from University of California, Davis. The author has contributed to research in topics: Gene & Genome. The author has an hindex of 74, co-authored 199 publications receiving 67145 citations. Previous affiliations of John Douglas Mcpherson include National University of Singapore & Case Western Reserve University.
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Journal ArticleDOI
Report of the Fourth International Workshop on Human Chromosome 5 mapping 1996.
TL;DR: The accomplishments of the Second International Workshop on Human Chromosome 5 as was held May 11--13,1992 at the University of Chicago are described.
Posted ContentDOI
Exosomes transmit retroelement RNAs to drive inflammation and immunosuppression in Ewing Sarcoma
Valentina Evdokimova,Valentina Evdokimova,P. Ruzanov,Hendrik Gassmann,Syed H.E. Zaidi,Vanya Peltekova,Lawrence E. Heisler,John Douglas Mcpherson,M Orlic-Milacic,Katja Specht,Katja Steiger,Sebastian J. Schober,Uwe Thiel,Trevor D. McKee,Mark Zaidi,Christopher M. Spring,Eve Lapouble,Olivier Delattre,Olivier Delattre,Stefan Burdach,Lincoln Stein,Poul H. Sorensen +21 more
TL;DR: It is established that EwS metastatic progression is accompanied by elevated plasma levels of multiple proinflammatory cytokines, interferons and extracellular vesicles (EVs), which were enriched with transcripts derived from LINE, SINE and ERV retroelements and from locus-specific pericentromeric regions, including HSAT2.
Journal Article
Fructose mediated crosslinking of proteins.
TL;DR: 10-20% of the hexose bound to human ocular lens proteins was found to be attached to epsilon-amino groups of lysyl residues via carbon 2, indicating that the proteins had undergone nonenzymatic reactions with endogenous fructose.
Journal ArticleDOI
Activation of hedgehog signaling associates with early disease progression in chronic lymphocytic leukemia.
Emanuela M. Ghia,Laura Z. Rassenti,Donna Neuberg,Alejandro Toro Blanco,Fouad Yousif,Erin N. Smith,John Douglas Mcpherson,Thomas J. Hudson,Olivier Harismendy,Kelly A. Frazer,Thomas J. Kipps +10 more
TL;DR: It is shown that a large proportion of patients with chronic lymphocytic leukemia have CLL cells with activated Hh signaling, which is associated with early disease progression and enhanced sensitivity to inhibition of GLI1.
Posted ContentDOI
A comprehensive multicenter comparison of whole genome sequencing pipelines using a uniform tumor-normal sample pair
Ivo Buchhalter,Barbara Hutter,Tyler Alioto,Timothy Beck,Paul C. Boutros,Benedikt Brors,Adam Butler,Sasithorn Chotewutmontri,Robert E. Denroche,Sophia Derdak,Nicolle Diessl,Lars Feuerbach,Fujimoto A,Susanne Gröbner,Gut M,Nicholas J. Harding,Michael Heinold,Lawrence E. Heisler,Jonathon Hinton,Natalie Jäger,David T. Jones,Rolf Kabbe,Andrey Korshunov,John Douglas Mcpherson,Andy Menzies,Hidewaki Nakagawa,Christopher Previti,Keiran Raine,Paolo Ribeca,Sabine Schmidt,Rebecca Shepherd,Lucy Stebbings,Patrick S. Tarpey,Jon W. Teague,Laurie Tonon,David A. Wheeler,Liu Xi,Takafumi N. Yamaguchi,Sertier A,Stefan M. Pfister,Peter J. Campbell,Matthias Schlesner,Peter Lichter,Roland Eils,Gut I,Jones Dtw +45 more
TL;DR: This benchmarking exercise has highlighted several fundamental parameters to consider in high-throughput sequencing, which will allow for better optimization and planning of both basic and translational studies.