John R. Crison

TL;DR: A biopharmaceutics drug classification scheme for correlating in vitro drug product dissolution and in vivo bioavailability is proposed based on recognizing that drug dissolution and gastrointestinal permeability are the fundamental parameters controlling rate and extent of drug absorption.

TL;DR: This study presents a meta-analysis of the phytochemical properties of seven novel drugs that have been developed over a period of several years and show promise in terms of protecting against adverse events and promoting drug safety.

TL;DR: This review focuses on the dynamic models, which predict both the fraction of dose absorbed and the rate of drug absorption and can be related to pharmacokinetic models to evaluate plasma concentration profiles.

TL;DR: It was demonstrated that the small intestinal transit flow profile was well characterized by both compartmental transit and dispersion models, but not by the single-compartment model, and it was concluded that the compartmental Transit model might be superior to thesingle-compartments model and less complex than the dispersion model.

TL;DR: This model may be useful in predicting the dissolution of an ionizable water insoluble drug as a function of pH and surfactant and for establishing in vitro-in vivo correlations, IVIVC, for maintaining bioequivalence of drug products.