J
John Simpson
Researcher at University of Southampton
Publications - 88
Citations - 10283
John Simpson is an academic researcher from University of Southampton. The author has contributed to research in topics: Nuclear weapon & Disarmament. The author has an hindex of 13, co-authored 87 publications receiving 10077 citations.
Papers
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Journal ArticleDOI
Genome sequencing in microfabricated high-density picolitre reactors
Marcel Margulies,Michael Egholm,William E. Altman,Said Attiya,Joel S. Bader,Lisa A. Bemben,Jan Berka,Michael S. Braverman,Yi-Ju Chen,Zhoutao Chen,Scott Dewell,Lei Du,J. M. Fierro,Xavier V. Gomes,Brian C. Godwin,Wen He,Scott Edward Helgesen,Chun Heen Ho,Gerard P. Irzyk,Szilveszter C. Jando,Maria L. I. Alenquer,Thomas P. Jarvie,Kshama B. Jirage,Jong-Bum Kim,James R. Knight,Janna R. Lanza,John H. Leamon,Steven Lefkowitz,Ming Lei,Jing Li,Kenton Lohman,Hong Lu,Vinod Makhijani,Keith Mcdade,Michael P. McKenna,Eugene W. Myers,Elizabeth Nickerson,John Nobile,Ramona Plant,Bernard P. Puc,Michael T. Ronan,George T. Roth,Gary J. Sarkis,Jan Fredrik Simons,John Simpson,Maithreyan Srinivasan,Karrie R. Tartaro,Alexander Tomasz,Kari A. Vogt,Greg A. Volkmer,Shally H. Wang,Yong Wang,Michael P. Weiner,Pengguang Yu,Richard F. Begley,Jonathan M. Rothberg +55 more
TL;DR: A scalable, highly parallel sequencing system with raw throughput significantly greater than that of state-of-the-art capillary electrophoresis instruments with 96% coverage at 99.96% accuracy in one run of the machine is described.
Patent
Method of sequencing a nucleic acid
Jonathan M. Rothberg,Joel S. Bader,Scott Dewell,Keith Mcdade,John Simpson,Jan Berka,Christopher M. Colangelo +6 more
TL;DR: In this article, methods and apparatuses for sequencing a nucleic acid are presented. But their methods require a large number of independent sequencing reactions to be arrayed in parallel, permitting simultaneous sequencing of a very large number (>10,000) of different oligonucleotides.
Patent
Method and apparatus for identifying classifying or quantifying DNA sequences in a sample without sequencing
TL;DR: In this article, the authors proposed methods by which biologically derived DNA sequences in a mixed sample or in an arrayed single sequence clone can be determined and classified without sequencing, making use of information on the presence of carefully chosen target subsequences, typically of length from 4 to 8 base pairs.
Patent
Apparatus and method for sequencing a nucleic acid
Jonathan M. Rothberg,Joel S. Bader,Scott Dewell,Keith Mcdade,John Simpson,Jane Berka,Christopher M. Colangelo,Michael P. Weiner +7 more
TL;DR: In this article, methods and apparatuses for sequencing a nucleic acid are presented. But their methods require a large number of independent sequencing reactions to be arrayed in parallel, permitting simultaneous sequencing of a very large number (>10,000) of different oligonucleotides.
Patent
Separation of charged particles by a spatially and temporally varying electric field
Joel S. Bader,Jonathan M. Rothberg,Michael W. Deem,Gregory T. Mulhern,Gregory T. Went,John Simpson,Steven A. Henck +6 more
TL;DR: In this paper, a device for separating charged particles comprising an upper substate (11), a lower substrate (12), separation lanes (15) defined on the upper substrate, a first plurality of electrodes (21, 22, 23), a first pad (18), a second pad (19, 20, 21, 22), a third pad (23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46,