Maithreyan Srinivasan

TL;DR: A scalable, highly parallel sequencing system with raw throughput significantly greater than that of state-of-the-art capillary electrophoresis instruments with 96% coverage at 99.96% accuracy in one run of the machine is described.

TL;DR: Examination of large-scale yeast two-hybrid screens reveals interactions that place functionally unclassified proteins in a biological context, interactions between proteins involved in the same biological function, and interactions that link biological functions together into larger cellular processes.

TL;DR: This sequence was completed in two months at approximately one-hundredth of the cost of traditional capillary electrophoresis methods and demonstrated the acquisition of novel human sequence, including novel genes not previously identified by traditional genomic sequencing, which is the first genome sequenced by next-generation technologies.

TL;DR: In this paper, a method for nucleic acid amplification is described, in which the templates, beads, and amplification reaction solution are emulsified and the nucleic acids are amplified to provide clonal copies of the templates attached to the beads.

TL;DR: In this paper, the authors proposed methods of sequencing both the sense and antisense strands of DNA through the use of blocked and unblocked sequencing primers, and they described the steps of annealing an unblockable primer to a first strand of nucleic acid, denoising a blocked primer to a second strand, and elongating the nucleic acids along the first strand with a polymerase.