Lei Du

TL;DR: A scalable, highly parallel sequencing system with raw throughput significantly greater than that of state-of-the-art capillary electrophoresis instruments with 96% coverage at 99.96% accuracy in one run of the machine is described.

TL;DR: High-throughput and massive paired-end mapping (PEM) was used to map SVs in an African and in a putatively European individual and identified shared and divergent SVs relative to the reference genome, documenting that the number of SVs among humans is much larger than initially hypothesized; many of the SVs potentially affect gene function.

TL;DR: A 38,000-year-old Neanderthal fossil that is exceptionally free of contamination from modern human DNA is identified and it is revealed that modern human and Neanderthal DNA sequences diverged on average about 500,000 years ago.

TL;DR: The use of high-throughput sequencing during an outbreak of disease facilitated the identification of a new arenavirus transmitted through solid-organ transplantation, related to lymphocytic choriomeningitis viruses.

TL;DR: This article used a massively parallel sequencing method that allows large numbers of single DNA strands to be sequenced, and showed that modifications of C, as well as to a lesser extent of G, residues cause such misincorporations.