J
Joke A. Bouwstra
Researcher at Leiden University
Publications - 375
Citations - 23433
Joke A. Bouwstra is an academic researcher from Leiden University. The author has contributed to research in topics: Stratum corneum & Corneocyte. The author has an hindex of 78, co-authored 368 publications receiving 20996 citations. Previous affiliations of Joke A. Bouwstra include VU University Amsterdam & University of Illinois at Urbana–Champaign.
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Journal ArticleDOI
Structure of the skin barrier and its modulation by vesicular formulations.
TL;DR: In order to unravel the mechanisms involved in increasing the drug transport across the skin, information on the effect of vesicles on drug permeation rate, the permeation pathway and perturbations of the skin ultrastructure is of importance.
Journal ArticleDOI
Structural Investigations of Human Stratum Corneum by Small-Angle X-Ray Scattering
Joke A. Bouwstra,Joke A. Bouwstra,Gert S. Gooris,Gert S. Gooris,Joop A van der Spek,Joop A van der Spek,Wim Bras,Wim Bras +7 more
TL;DR: The structure of human stratum corneum was investigated with small-angle X-ray scattering (SAXS) and it is concluded that in the original curve the lipids are arranged in two unit cells with repeat distances of 6.4 nm and 13.
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Liposomes and niosomes as topical drug carriers: dermal and transdermal drug delivery
Hans Schreier,Joke A. Bouwstra +1 more
TL;DR: It is concluded that liposomes and niosomes may become a useful dosage form for a variety of dermally active compounds, specifically due to their ability to modulate drug transfer and serve as nontoxic penetration enhancers.
Journal ArticleDOI
The skin barrier in healthy and diseased state.
Joke A. Bouwstra,Maria Ponec +1 more
TL;DR: The lipid organization in stratum corneum of normal and diseased skin is described and the role the various lipid classes play in strata corneum lipid organization and barrier function has been discussed.
Journal ArticleDOI
Microneedle technologies for (trans)dermal drug and vaccine delivery.
TL;DR: This review describes different production methods for solid and hollow microneedles as well as conditions that influence skin penetration and the view on research and development that is needed to rendermicroneedle-based (trans)dermal drug delivery technologies clinically useful in the near future.