J
Joke A. Bouwstra
Researcher at Leiden University
Publications - 375
Citations - 23433
Joke A. Bouwstra is an academic researcher from Leiden University. The author has contributed to research in topics: Stratum corneum & Corneocyte. The author has an hindex of 78, co-authored 368 publications receiving 20996 citations. Previous affiliations of Joke A. Bouwstra include VU University Amsterdam & University of Illinois at Urbana–Champaign.
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Journal ArticleDOI
Physicochemical characterization of drug-loaded rigid and elastic vesicles.
TL;DR: The chemical stability of ketorolac was dramatically improved in the vesicle formulation compared to a buffer solution, and the strong interactions of ket orolac with the bilayers of the vESicles might be the explanation for this increased stability.
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Predicting the optimal geometry of microneedles and their array for dermal vaccination using a computational model
TL;DR: A computational model was developed to predict the optimal design of the microneedles and their arrangement within an array and revealed the importance of various geometric parameters to enhance the induced immune response.
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Skin of atopic dermatitis patients shows disturbed β-glucocerebrosidase and acid sphingomyelinase activity that relates to changes in stratum corneum lipid composition
Daphne E.C. Boer,Jeroen van Smeden,Hanin Al-Khakany,Elizaveta Melnik,Rianne van Dijk,Samira Absalah,Rob J. Vreeken,Caroline C P Haenen,A.P.M. Lavrijsen,Herman S. Overkleeft,Johannes M. F. G. Aerts,Joke A. Bouwstra +11 more
TL;DR: This research highlights the relation between correct localization of expressed and active lipid enzymes and a normal SC lipid composition for a proper skin barrier.
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Parameter optimization toward optimal microneedle-based dermal vaccination.
Koen van der Maaden,Eleni Maria Varypataki,Huixin Yu,Stefan Romeijn,Wim Jiskoot,Joke A. Bouwstra +5 more
TL;DR: It was shown that the ovalbumin-specific antibody responses upon microneedle-based vaccination could be increased up to 12-fold when an impact-insertion applicator was used, up to 8- fold when micronees were applied over a larger surface area, and up to 36-fold dependent on the location of micronee application.
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Human skin equivalents: Impaired barrier function in relation to the lipid and protein properties of the stratum corneum
TL;DR: In this article, the authors provide an overview of established in-house and commercially available 3D-human skin equivalents and discuss in more detail to what extent their skin barrier biology is mimicked in vitro focusing on the lipid properties and cornified envelope.