Joke A. Bouwstra

TL;DR: Pilgram et al. as discussed by the authors used electron diffraction (ED) to examine the influence of two azones and sebaceous lipids on the lateral phase behavior of lipids isolated from human stratum corneum.

TL;DR: It was concluded that in the CHOL/CER mixtures a lower relative amount of CHOL was required to acquire these lamellar phases, indicating that at low CHOL contents, CER 3, 4, 5 and 6 play a crucial role in the formation of the lameLLar phases.

TL;DR: Data show that encapsulation of antigen and adjuvant into a cationic liposome has a beneficial effect on the quality of the antibody response in mice after intranodal or intradermal immunization, but impairs proper delivery to the lymph nodes when the formulations are administered transcutaneously or nasally.

TL;DR: It is essential that drug molecules are applied together with and entrapped within the vesicle themselves, suggesting that elastic vesicles act as drug carrier systems and not solely as penetration enhancers.

TL;DR: In this paper, it was shown that the formation of a mucoadhesive bond is primarily governed by the aforementioned surface energy effects and spreading processes, and that individual spreading coefficients, as calculated from these surface energy parameters by the geometric mean equation, can be combined to one single parameter, called combined spreading coefficient S C.