J
Joke A. Bouwstra
Researcher at Leiden University
Publications - 375
Citations - 23433
Joke A. Bouwstra is an academic researcher from Leiden University. The author has contributed to research in topics: Stratum corneum & Corneocyte. The author has an hindex of 78, co-authored 368 publications receiving 20996 citations. Previous affiliations of Joke A. Bouwstra include VU University Amsterdam & University of Illinois at Urbana–Champaign.
Papers
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Journal ArticleDOI
Effect of synthetic vernix biofilms on barrier recovery of damaged mouse skin
Marion H.M. Oudshoorn,Robert Rissmann,Dennis van der Coelen,Wim E. Hennink,Maria Ponec,Joke A. Bouwstra +5 more
TL;DR: Observations suggest the potential use of this biofilm treatment clinically, as the importance of the presence of individual components, i.e. barrier lipids and water, as well as the ratio of these components is indicated.
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The effects of LXR agonist T0901317 and LXR antagonist GSK2033 on morphogenesis and lipid properties in full thickness skin models
Richard W.J. Helder,Walter A. Boiten,Rianne van Dijk,G.S. Gooris,Abdoelwaheb El Ghalbzouri,Joke A. Bouwstra +5 more
TL;DR: It is demonstrated that LXR deactivation led to the development of FTMs with improved lipid properties, which mimic the lipid composition of NHS more closely, whereas LXR activation increased the amount of monounsaturated lipids and led to a reduction in the overall chain length.
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Effect of elastic liquid-state vesicle on apomorphine iontophoresis transport through human skin in vitro
TL;DR: This study investigated whether treatment with elastic vesicles can be used to enhance apomorphine iontophoretic delivery and prepared an elastic liquid-state vesicle suspension prepared from polyoxyethylene ester PEG-8-L, sucrose-ester L595, and cholesterol sulfate at a molar ratio of 70: 30: 5.
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The in vitro and in vivo evaluation of new synthesized prodrugs of 5-OH-DPAT for iontophoretic delivery
Oliver W. Ackaert,J. De Graan,Romano Capancioni,O.E. Della Pasqua,Durk Dijkstra,Ben H.C. Westerink,Meindert Danhof,Joke A. Bouwstra +7 more
TL;DR: Beta-alanine-5-OH-DPAT is a promising prodrug, with a good balance between stability, transport efficiency and enzymatic conversion, investigated in vitro and in vivo.
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The effect of microfluidization of protein-coated liposomes on protein distribution on the surface of generated small vesicles.
TL;DR: Tetanus toxoid and immunoglobulin G (IgG), model proteins for vaccines and targeting ligands respectively, were covalently coupled to preformed dehydration-rehydration vesicles (DRV) to produce vesicle with surface-bound proteins (DRv-protein) or to pre formed small unilamellar ves Balls (SUV) which were used to generate DRV with bound protein [(SUV- protein)DRV].