J
Joke A. Bouwstra
Researcher at Leiden University
Publications - 375
Citations - 23433
Joke A. Bouwstra is an academic researcher from Leiden University. The author has contributed to research in topics: Stratum corneum & Corneocyte. The author has an hindex of 78, co-authored 368 publications receiving 20996 citations. Previous affiliations of Joke A. Bouwstra include VU University Amsterdam & University of Illinois at Urbana–Champaign.
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Journal ArticleDOI
Elasticity of vesicles assessed by electron spin resonance, electron microscopy and extrusion measurements.
TL;DR: When the molar content of the single chain non-ionic surfactant PEG-8-L in vesicles is increased the elasticity is enhanced and the rotational correlation time is reduced, which might contribute to an optimal design of vesicle bilayers as drug carriers for transdermal application.
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The lipid organisation in the skin barrier.
TL;DR: A short description of the lipid organisation in normal human stratum corneum will be given, after which the role the main lipid classes play in the stratum Corneum lipid organisation will be described and a new model, the "sandwich model", will be proposed that describe the localisation of the fluid phases in the Stratum cor pneumonia.
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Administration routes affect the quality of immune responses: A cross-sectional evaluation of particulate antigen-delivery systems
Deepa Mohanan,Bram Slütter,Malou Henriksen-Lacey,Wim Jiskoot,Joke A. Bouwstra,Yvonne Perrie,Thomas M. Kündig,Bruno Gander,Pål Johansen +8 more
TL;DR: The results show that the IgG2aassociated with Th1-type immune responses are sensitive to the route of administration, whereas IgG1 response associated with Th2- type immune responses were relatively insensitive to the administration route of the particulate delivery systems.
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Assembled microneedle arrays enhance the transport of compounds varying over a large range of molecular weight across human dermatomed skin.
F.J. Verbaan,Suzanne M. Bal,D.J. van den Berg,Whh Groenink,Henk Verpoorten,Regina Luttge,Joke A. Bouwstra +6 more
TL;DR: It is concluded that assembled microneedle arrays can be used to deliver compounds through the skin up to a molecular weight of at least 72 kDa.
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Nasal vaccination with N-trimethyl chitosan and PLGA based nanoparticles: nanoparticle characteristics determine quality and strength of the antibody response in mice against the encapsulated antigen.
Bram Slütter,Suzanne M. Bal,Chantal Keijzer,Roel Mallants,Niels Hagenaars,Ivo Que,Eric L. Kaijzel,Willem van Eden,Patrick Augustijns,Clemens W.G.M. Löwik,Joke A. Bouwstra,Femke Broere,Wim Jiskoot +12 more
TL;DR: For nasal vaccination, TMC NP, releasing their content within several hours, being mucoadhesive and stimulating the maturation of DC, were superior to PLGA NP and PLGA/TMC NP which lacked some or all of these characteristics.