J
Joke A. Bouwstra
Researcher at Leiden University
Publications - 375
Citations - 23433
Joke A. Bouwstra is an academic researcher from Leiden University. The author has contributed to research in topics: Stratum corneum & Corneocyte. The author has an hindex of 78, co-authored 368 publications receiving 20996 citations. Previous affiliations of Joke A. Bouwstra include VU University Amsterdam & University of Illinois at Urbana–Champaign.
Papers
More filters
Journal ArticleDOI
Application of vesicles to rat skin in vivo: a confocal laser scanning microscopy study.
TL;DR: The vesicular form and the thermodynamic state of the bilayer and to a smaller extent the flexibility of thebilayer influence the penetration depth of the label into the skin at longer application periods, in good agreement with CLSM results obtained from in vitro experiments with human skin.
Journal ArticleDOI
Characterization of stratum corneum molecular dynamics by natural-abundance 13C solid-state NMR
TL;DR: Novel molecular insight is provided into how the SC constituents are affected by hydration and heating, and the understanding of enhanced SC permeability, which is associated with elevated temperatures and SC hydration is improved.
Journal ArticleDOI
Modelling the stratum corneum lipid organisation with synthetic lipid mixtures: the importance of synthetic ceramide composition.
TL;DR: It is demonstrated that the CER3 to SigmaCERIV ratio affects the formation of the 13-nm lamellar phase and that the optimal ratio depends on the presence of FFA.
Journal ArticleDOI
Effect of divalent cations on lipid organization of cardiolipin isolated from Escherichia coli strain AH930.
J. Antoinette Killian,Martijn C. Koorengevel,Joke A. Bouwstra,Gert S. Gooris,William Dowhan,Ben de Kruijff +5 more
TL;DR: Cardiolipin with divalent cations can replace the role of phosphatidylethanolamine in the mutant strain, and that this role involves the preference of these lipids for organization in non-bilayer lipid structures.
Journal ArticleDOI
Cholesterol sulfate and calcium affect stratum corneum lipid organization over a wide temperature range
TL;DR: It seems that cholesterol sulfate is required to dissolve cholesterol in the lamellar phases of the SC and to stabilize SC lipid organization, and the finding that Ca(2+) counteracts the effects ofolesterol sulfate indicates the importance of a proper balance of minor SC components for appropriateSC lipid organization.