J
Jon S. Brazier
Researcher at University Hospital of Wales
Publications - 98
Citations - 9246
Jon S. Brazier is an academic researcher from University Hospital of Wales. The author has contributed to research in topics: Clostridium difficile & Fusobacterium necrophorum. The author has an hindex of 45, co-authored 97 publications receiving 8855 citations.
Papers
More filters
Journal ArticleDOI
Toxin production by an emerging strain of Clostridium difficile associated with outbreaks of severe disease in North America and Europe
Michel Warny,Jacques Pépin,Aiqi Fang,George Killgore,Angela Thompson,Jon S. Brazier,Eric Frost,L. Clifford McDonald +7 more
TL;DR: The severity of C difficile-associated disease caused by NAP1/027 could result from hyperproduction of toxins A and B, and dissemination of this strain in North America and Europe could lead to important changes in the epidemiology of C diffusion disease.
Journal ArticleDOI
Clostridium difficile infection in Europe: a hospital-based survey
Martijn P. Bauer,Daan W. Notermans,Birgit H. B. van Benthem,Jon S. Brazier,Mark H. Wilcox,Maja Rupnik,Dominique L Monnet,Jaap T. van Dissel,Ed J. Kuijper +8 more
TL;DR: The data emphasise the importance of multicountry surveillance to detect and control C difficile infection in Europe and build capacity for diagnosis and surveillance.
Journal ArticleDOI
PCR Targeted to the 16S-23S rRNA Gene Intergenic Spacer Region of Clostridium difficile and Construction of a Library Consisting of 116 Different PCR Ribotypes
TL;DR: A reference library of types of Clostridium difficile has been constructed by PCR ribotyping isolates from environmental, hospital, community practitioner, veterinary, and reference sources, consisting of 116 distinct types identified on the basis of differences in profiles generated with PCR primers designed to amplify the 16S-23S rRNA gene intergenic spacer region.
Journal ArticleDOI
Production of actin‐specific ADP‐ribosyltransferase (binary toxin) by strains of Clostridium difficile
Simon L. J. Stubbs,Maja Rupnik,Maryse Gibert,Jon S. Brazier,Brian I. Duerden,Michel R. Popoff +5 more
TL;DR: Results indicate that 6.4% of toxigenic isolates of C. difficile referred to the Anaerobe Reference Unit from UK hospitals have cdtA and cdtB genes.
Journal ArticleDOI
Comparison of Seven Techniques for Typing International Epidemic Strains of Clostridium difficile: Restriction Endonuclease Analysis, Pulsed-Field Gel Electrophoresis, PCR-Ribotyping, Multilocus Sequence Typing, Multilocus Variable-Number Tandem-Repeat Analysis, Amplified Fragment Length Polymorphism, and Surface Layer Protein A Gene Sequence Typing
George Killgore,Angela Thompson,Stuart Johnson,Jon S. Brazier,Ed J. Kuijper,Jacques Pépin,Eric Frost,Paul H. M. Savelkoul,Brad Nicholson,Renate J. van den Berg,Haru Kato,Susan P. Sambol,Walter Zukowski,Christopher W. Woods,Brandi Limbago,Dale N. Gerding,L. Clifford McDonald +16 more
TL;DR: All techniques appear to be capable of detecting outbreak strains, but only REA and MLVA showed sufficient discrimination to distinguish strains from different outbreaks.