J
Jonas Paulsen
Researcher at University of Oslo
Publications - 30
Citations - 1643
Jonas Paulsen is an academic researcher from University of Oslo. The author has contributed to research in topics: Genome & Chromosome conformation capture. The author has an hindex of 16, co-authored 28 publications receiving 1375 citations. Previous affiliations of Jonas Paulsen include Oslo University Hospital & University of Iceland.
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Journal ArticleDOI
The genome sequence of Atlantic cod reveals a unique immune system
Bastiaan Star,Alexander J. Nederbragt,Sissel Jentoft,Unni Grimholt,Martin Malmstrøm,Tone F. Gregers,Trine B. Rounge,Jonas Paulsen,Jonas Paulsen,Monica Hongrø Solbakken,Animesh Sharma,Ola F. Wetten,Ola F. Wetten,Anders Lanzén,Roger Winer,James D.R. Knight,Jan-Hinnerk Vogel,Bronwen Aken,Øivind Andersen,Karin Lagesen,Ave Tooming-Klunderud,Rolf B. Edvardsen,Kirubakaran G. Tina,Kirubakaran G. Tina,Mari Espelund,Chirag Nepal,Christopher Previti,Bård Ove Karlsen,Truls Moum,Morten Skage,Paul R. Berg,Tor Gjøen,Heiner Kuhl,Jim Thorsen,Ketil Malde,Richard Reinhardt,Lei Du,Steinar Johansen,Steinar Johansen,Steve Searle,Sigbjørn Lien,Frank Nilsen,Inge Jonassen,Stig W. Omholt,Stig W. Omholt,Nils Christian Stenseth,Kjetill S. Jakobsen +46 more
TL;DR: The genome sequence of Atlantic cod is presented, showing evidence for complex thermal adaptations in its haemoglobin gene cluster and an unusual immune architecture compared to other sequenced vertebrates.
Journal ArticleDOI
Chrom3D: three-dimensional genome modeling from Hi-C and nuclear lamin-genome contacts
Jonas Paulsen,Monika Sekelja,Anja R. Oldenburg,Alice Barateau,Nolwenn Briand,Erwan Delbarre,Akshay Shah,Anita L. Sørensen,Corinne Vigouroux,Brigitte Buendia,Philippe Collas,Philippe Collas +11 more
TL;DR: Chrom3D reveals unexpected spatial features of LAD regulation in cells from patients with a laminopathy-causing lamin mutation, and simulates positions of topologically-associated domains (TADs) relative to each other and to the nuclear periphery.
Journal ArticleDOI
Long-range interactions between topologically associating domains shape the four-dimensional genome during differentiation.
Jonas Paulsen,Tharvesh Moideen Liyakat Ali,Maxim Nekrasov,Erwan Delbarre,Marie-Odile Baudement,Sebastian Kurscheid,David J. Tremethick,Philippe Collas,Philippe Collas +8 more
TL;DR: The authors identify the formation of dynamic topologically associating domain (TAD) cliques during differentiation and reprogramming and analysis indicates that TAD cliques stabilize heterochromatin at the nuclear periphery.
Journal ArticleDOI
The Regulatory Landscape of Osteogenic Differentiation
Anne Mari Håkelien,Jan Christian Bryne,Kristine G. Harstad,Susanne Lorenz,Jonas Paulsen,Jinchang Sun,Tarjei S. Mikkelsen,Ola Myklebost,Leonardo A. Meza-Zepeda +8 more
TL;DR: This work provides a first genome‐wide characterization of DNA binding sites of the bone master regulatory transcription factor Runt‐related transcription factor 2 (RUNX2) in human osteoblasts, revealing target genes associated with regulation of proliferation, migration, apoptosis, and with a significant overlap with p53 regulated genes.
Journal ArticleDOI
Carcinogen susceptibility is regulated by genome architecture and predicts cancer mutagenesis
Pablo E. García-Nieto,Erin K. Schwartz,Devin A. King,Jonas Paulsen,Philippe Collas,Rafael E. Herrera,Ashby J. Morrison +6 more
TL;DR: This study presents the first quantitative human genome‐wide map of DNA lesions induced by ultraviolet (UV) radiation, the ubiquitous carcinogen in sunlight that causes skin cancer, and identifies carcinogen susceptibility as an origin of genome instability that is regulated by nuclear architecture and mirrors mutagenesis in cancer.