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Unni Grimholt
Researcher at Norwegian University of Life Sciences
Publications - 52
Citations - 4094
Unni Grimholt is an academic researcher from Norwegian University of Life Sciences. The author has contributed to research in topics: MHC class I & Major histocompatibility complex. The author has an hindex of 28, co-authored 49 publications receiving 3602 citations. Previous affiliations of Unni Grimholt include University of Oslo.
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Journal ArticleDOI
The Atlantic salmon genome provides insights into rediploidization
Sigbjørn Lien,Ben F. Koop,Simen Rød Sandve,Jason R. Miller,Matthew Peter Kent,Torfinn Nome,Torgeir R. Hvidsten,Torgeir R. Hvidsten,Jong S. Leong,David R. Minkley,Aleksey V. Zimin,Fabian Grammes,Harald Grove,Arne B. Gjuvsland,Brian P. Walenz,Russell A. Hermansen,Russell A. Hermansen,Kristian R. von Schalburg,Eric Rondeau,Alex Di Genova,Jeevan Karloss Antony Samy,Jon Olav Vik,Magnus Dehli Vigeland,Lis Caler,Unni Grimholt,Sissel Jentoft,Dag Inge Våge,Pieter J. de Jong,Thomas Moen,Matthew Baranski,Yniv Palti,Douglas W. Smith,James A. Yorke,Alexander J. Nederbragt,Ave Tooming-Klunderud,Kjetill S. Jakobsen,Xuanting Jiang,Dingding Fan,Yan Hu,David A. Liberles,Richard Vidal,Patricia Iturra,Steven J.M. Jones,Steven J.M. Jones,Inge Jonassen,Alejandro Maass,Stig W. Omholt,William S. Davidson +47 more
TL;DR: It is found that genes that were retained as duplicates after the teleost-specific whole-genome duplication 320 million years ago were not more likely to be retained after the Ss4R, and that the duplicate retention was not influenced to a great extent by the nature of the predicted protein interactions of the gene products.
Journal ArticleDOI
The genome sequence of Atlantic cod reveals a unique immune system
Bastiaan Star,Alexander J. Nederbragt,Sissel Jentoft,Unni Grimholt,Martin Malmstrøm,Tone F. Gregers,Trine B. Rounge,Jonas Paulsen,Jonas Paulsen,Monica Hongrø Solbakken,Animesh Sharma,Ola F. Wetten,Ola F. Wetten,Anders Lanzén,Roger Winer,James D.R. Knight,Jan-Hinnerk Vogel,Bronwen Aken,Øivind Andersen,Karin Lagesen,Ave Tooming-Klunderud,Rolf B. Edvardsen,Kirubakaran G. Tina,Kirubakaran G. Tina,Mari Espelund,Chirag Nepal,Christopher Previti,Bård Ove Karlsen,Truls Moum,Morten Skage,Paul R. Berg,Tor Gjøen,Heiner Kuhl,Jim Thorsen,Ketil Malde,Richard Reinhardt,Lei Du,Steinar Johansen,Steinar Johansen,Steve Searle,Sigbjørn Lien,Frank Nilsen,Inge Jonassen,Stig W. Omholt,Stig W. Omholt,Nils Christian Stenseth,Kjetill S. Jakobsen +46 more
TL;DR: The genome sequence of Atlantic cod is presented, showing evidence for complex thermal adaptations in its haemoglobin gene cluster and an unusual immune architecture compared to other sequenced vertebrates.
Journal ArticleDOI
MHC polymorphism and disease resistance in Atlantic salmon (Salmo salar); facing pathogens with single expressed major histocompatibility class I and class II loci
Unni Grimholt,Stig Larsen,Rolf Nordmo,Paul J. Midtlyng,Sissel Kjoeglum,Arne Storset,Solve Sæbø,René J. M. Stet +7 more
TL;DR: It is found that there are highly significant associations between resistance towards infectious diseases caused by both pathogens and MH class I and class II polymorphism in Atlantic salmon.
Journal ArticleDOI
Validation of Reference Genes for Real-Time Polymerase Chain Reaction Studies in Atlantic Salmon
TL;DR: Between tissues, 18S and EF1A were most stable, RPL1 and RPL2 were intermediate, and G6PDH and ACTB and B2M were the least stable, but only 18S had constant expression in infected cells; the rest significantly down-regulated.
Journal ArticleDOI
The major histocompatibility class I locus in Atlantic salmon ( Salmo salar L.): polymorphism, linkage analysis and protein modelling
TL;DR: Protein modelling of several Sasa-UBA alleles shows distinct differences in their peptide binding domains and enables a further understanding of the functionality of the high polymorphism, which strengthens the claim that SaaB is the major Mhc class I locus in Atlantic salmon.