J
Jonathan Lytton
Researcher at University of Calgary
Publications - 84
Citations - 12063
Jonathan Lytton is an academic researcher from University of Calgary. The author has contributed to research in topics: SERCA & Endoplasmic reticulum. The author has an hindex of 43, co-authored 80 publications receiving 11664 citations. Previous affiliations of Jonathan Lytton include Brigham and Women's Hospital & University of Cincinnati Academic Health Center.
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Journal ArticleDOI
Cloning and characterization of an extracellular Ca 2+ -sensing receptor from bovine parathyroid
Edward M. Brown,Gerardo Gamba,Daniela Riccardi,Michael Lombardi,Robert Butters,Olga Kifor,Adam Sun,Adam Sun,Matthias A. Hediger,Jonathan Lytton,Steven C. Hebert +10 more
TL;DR: The cloning of complementary DNA encoding an extracellular Ca2+ -sensing receptor from bovine parathyroid is reported with pharmacological and functional properties nearly identical to those of the native receptor.
Journal ArticleDOI
Thapsigargin inhibits the sarcoplasmic or endoplasmic reticulum Ca-ATPase family of calcium pumps.
TL;DR: The role of ATP-dependent calcium uptake into intracellular storage compartments is an essential feature of hormonally induced calcium signaling Thapsigargin, a non-phorboid tumor promoter, increasingly is being used to manipulate calcium stores because it induces a hormone-like elevation of cytosolic calcium as discussed by the authors.
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Cloning and expression of an inwardly rectifying ATP-regulated potassium channel
Kevin Ho,Colin G. Nichols,W. J. Lederer,Jonathan Lytton,Peter M. Vassilev,M V Kanazirska,S.C. Hebert +6 more
TL;DR: A complementary DNA encoding an ATP-regulated potassium channel has been isolated by expression cloning from rat kidney and the presence of an H5 region, which is likely to form the ion conduction pathway, indicates that the protein may share a common origin with voltage-gated potassium channel proteins.
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Functional comparisons between isoforms of the sarcoplasmic or endoplasmic reticulum family of calcium pumps.
TL;DR: These properties are consistent with an enzyme in which the equilibrium between the E1 and E2 conformations is shifted toward the E2 state.
Journal ArticleDOI
Molecular cloning, primary structure, and characterization of two members of the mammalian electroneutral sodium-(potassium)-chloride cotransporter family expressed in kidney.
Gerardo Gamba,Akihiko Miyanoshita,Michael Lombardi,Jonathan Lytton,Wen Sen Lee,Matthias A. Hediger,Steven C. Hebert +6 more
TL;DR: Northern blot analysis and in situ hybridization indicate that these transporters are expressed predominantly in kidney with an intrarenal distribution consistent with their recognized functional localization, establishing a new family of Na(+)-(K+)-Cl- cotransporters.