M
Michael Lombardi
Researcher at Brigham and Women's Hospital
Publications - 13
Citations - 6067
Michael Lombardi is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Gene expression & Regulation of gene expression. The author has an hindex of 12, co-authored 13 publications receiving 5901 citations. Previous affiliations of Michael Lombardi include Harvard University & University of Massachusetts Boston.
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Journal ArticleDOI
Cloning and characterization of an extracellular Ca 2+ -sensing receptor from bovine parathyroid
Edward M. Brown,Gerardo Gamba,Daniela Riccardi,Michael Lombardi,Robert Butters,Olga Kifor,Adam Sun,Adam Sun,Matthias A. Hediger,Jonathan Lytton,Steven C. Hebert +10 more
TL;DR: The cloning of complementary DNA encoding an extracellular Ca2+ -sensing receptor from bovine parathyroid is reported with pharmacological and functional properties nearly identical to those of the native receptor.
Journal ArticleDOI
The MicroArray Quality Control (MAQC) project shows inter- and intraplatform reproducibility of gene expression measurements
Leming Shi,Laura H. Reid,Wendell D. Jones,Richard Shippy,Janet A. Warrington,Shawn C. Baker,Patrick J. Collins,Francoise de Longueville,Ernest S. Kawasaki,Kathleen Y. Lee,Yuling Luo,Yongming Andrew Sun,James C. Willey,Robert Setterquist,Gavin M. Fischer,Weida Tong,Yvonne P. Dragan,David J. Dix,Felix W. Frueh,Federico Goodsaid,Damir Herman,Roderick V. Jensen,Charles D. Johnson,Edward K. Lobenhofer,Raj K. Puri,Uwe Scherf,Jean Thierry-Mieg,Charles Wang,Michael A Wilson,Paul K. Wolber,Lu Zhang,William Slikker,Shashi Amur,Wenjun Bao,Catalin Barbacioru,Anne Bergstrom Lucas,Vincent Bertholet,Cecilie Boysen,Bud Bromley,Donna Brown,Alan Brunner,Roger D. Canales,Xiaoxi Megan Cao,Thomas A. Cebula,James J. Chen,Jing Cheng,Tzu Ming Chu,Eugene Chudin,John F. Corson,J. Christopher Corton,Lisa J. Croner,Christopher Davies,Timothy Davison,Glenda C. Delenstarr,Xutao Deng,David Dorris,Aron Charles Eklund,Xiaohui Fan,Hong Fang,Stephanie Fulmer-Smentek,James C. Fuscoe,Kathryn Gallagher,Weigong Ge,Lei Guo,Xu Guo,Janet Hager,Paul K. Haje,Jing Han,Tao Han,Heather Harbottle,Stephen C. Harris,Eli Hatchwell,Craig A. Hauser,Susan D. Hester,Huixiao Hong,Patrick Hurban,Scott A. Jackson,Hanlee P. Ji,Charles R. Knight,Winston Patrick Kuo,J. Eugene LeClerc,Shawn Levy,Quan Zhen Li,Chunmei Liu,Ying Liu,Michael Lombardi,Yunqing Ma,Scott R. Magnuson,Botoul Maqsodi,Timothy K. McDaniel,Nan Mei,Ola Myklebost,Baitang Ning,Natalia Novoradovskaya,Michael S. Orr,Terry Osborn,Adam Papallo,Tucker A. Patterson,Roger Perkins,Elizabeth Herness Peters,Ron L. Peterson,Kenneth L. Philips,P. Scott Pine,Lajos Pusztai,Feng Qian,Hongzu Ren,Mitch Rosen,Barry A. Rosenzweig,Raymond R. Samaha,Mark Schena,Gary P. Schroth,Svetlana Shchegrova,Dave D. Smith,Frank Staedtler,Zhenqiang Su,Hongmei Sun,Zoltan Szallasi,Zivana Tezak,Danielle Thierry-Mieg,Karol L. Thompson,Irina Tikhonova,Yaron Turpaz,Beena Vallanat,Christophe Van,Stephen J. Walker,Sue Jane Wang,Yonghong Wang,Russell D. Wolfinger,Alexander Wong,Jie Wu,Chunlin Xiao,Qian Xie,Jun Xu,Wen Yang,Liang Zhang,Sheng Zhong,Yaping Zong +136 more
TL;DR: This study describes the experimental design and probe mapping efforts behind the MicroArray Quality Control project and shows intraplatform consistency across test sites as well as a high level of interplatform concordance in terms of genes identified as differentially expressed.
Journal ArticleDOI
Molecular cloning, primary structure, and characterization of two members of the mammalian electroneutral sodium-(potassium)-chloride cotransporter family expressed in kidney.
Gerardo Gamba,Akihiko Miyanoshita,Michael Lombardi,Jonathan Lytton,Wen Sen Lee,Matthias A. Hediger,Steven C. Hebert +6 more
TL;DR: Northern blot analysis and in situ hybridization indicate that these transporters are expressed predominantly in kidney with an intrarenal distribution consistent with their recognized functional localization, establishing a new family of Na(+)-(K+)-Cl- cotransporters.
Journal ArticleDOI
Primary structure and functional expression of a cDNA encoding the thiazide-sensitive, electroneutral sodium-chloride cotransporter
Gerardo Gamba,Samuel N. Saltzberg,Michael Lombardi,Akihiko Miyanoshita,Jonathan Lytton,Matthias A. Hediger,Barry M. Brenner,Steven C. Hebert +7 more
TL;DR: The pharmacological and kinetic characteristics of the cloned cotransporter are consistent with the properties of native thiazide-sensitive, electroneutral sodium-chloride cOTransporters in teleost urinary bladder and mammalian renal distal tubule epithelia.
Journal ArticleDOI
A sequence-oriented comparison of gene expression measurements across different hybridization-based technologies
Winston Patrick Kuo,Winston Patrick Kuo,Fang Liu,Jeffrey M. Trimarchi,Claudio Punzo,Michael Lombardi,Jasjit Sarang,Mark E. Whipple,Malini Maysuria,Kyle A. Serikawa,Sun Young Lee,Donald J. McCrann,Jason Kang,Jeffrey R. Shearstone,Jocelyn Burke,Jocelyn Burke,Daniel J. Park,Daniel J. Park,Xiaowei Wang,Trent Rector,Paola Ricciardi-Castagnoli,Steven Perrin,Sangdun Choi,Roger E. Bumgarner,Junil Kim,Glenn F. Short,Glenn F. Short,Mason W. Freeman,Mason W. Freeman,Brian Seed,Brian Seed,Roderick V. Jensen,George M. Church,Eivind Hovig,Connie Cepko,Peter J. Park,Lucila Ohno-Machado,Tor Kristian Jenssen +37 more
TL;DR: Using probe sequences matched at the exon level improved consistency of measurements across the different microarray platforms compared to annotation-based matches, and generally, consistency was good for highly expressed genes, and variable for genes with lower expression values as confirmed by quantitative real-time (QRT)-PCR.