J
Jonathan Z. Long
Researcher at Stanford University
Publications - 83
Citations - 12581
Jonathan Z. Long is an academic researcher from Stanford University. The author has contributed to research in topics: JZL184 & Fatty acid amide hydrolase. The author has an hindex of 37, co-authored 69 publications receiving 10665 citations. Previous affiliations of Jonathan Z. Long include Kettering University & Harvard University.
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Journal ArticleDOI
Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system
Joel E. Schlosburg,Jacqueline L. Blankman,Jonathan Z. Long,Daniel K. Nomura,Bin Pan,Steven G. Kinsey,Peter T. Nguyen,Divya Ramesh,Lamont Booker,James J. Burston,Elizabeth A. Thomas,Dana E. Selley,Laura J. Sim-Selley,Qing-song Liu,Aron H. Lichtman,Benjamin F. Cravatt +15 more
TL;DR: Individual endocannabinoids generate distinct analgesic profiles that are either sustained or transitory and associated with agonism and functional antagonism of the brain cannabinoid system, respectively.
Journal ArticleDOI
Discovery and Characterization of a Highly Selective FAAH Inhibitor that Reduces Inflammatory Pain
Kay Ahn,Douglas S. Johnson,Mauro Mileni,David Beidler,Jonathan Z. Long,Michele K. McKinney,Eranthie Weerapana,Nalini Sadagopan,Marya Liimatta,Sarah E. Smith,Lazerwith Scott E,Cory Michael Stiff,Satwik Kamtekar,Keshab Bhattacharya,Yanhua Zhang,Stephen Swaney,Keri Van Becelaere,Raymond C. Stevens,Benjamin F. Cravatt +18 more
TL;DR: Mechanistic and structural studies confirm that PF-3845 is a covalent inhibitor that carbamylates FAAH's serine nucleophile, and designate PF- 3845 as a valuable pharmacological tool for in vivo characterization of the endocannabinoid system.
Journal ArticleDOI
The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors
William R. Marrs,Jacqueline L. Blankman,Eric A. Horne,Aurore Thomazeau,Yi Hsing Lin,Jonathan Coy,Ágnes L. Bodor,Giulio G. Muccioli,Sherry Shu Jung Hu,Grace Woodruff,Susan Fung,Mathieu Lafourcade,Jessica P. Alexander,Jonathan Z. Long,Weiwei Li,Cong Xu,Thomas Möller,Ken Mackie,Olivier J. Manzoni,Benjamin F. Cravatt,Nephi Stella +20 more
TL;DR: The results indicate that ABHD6 is a rate-limiting step of 2-AG signaling and is therefore a bona fide member of the endocannabinoid signaling system.
Journal ArticleDOI
A Smooth Muscle-Like Origin for Beige Adipocytes
Jonathan Z. Long,Katrin J. Svensson,Linus T.-Y. Tsai,Xing Zeng,Hyun Cheol Roh,Xingxing Kong,Rajesh R. Rao,Jesse Lou,Isha A. Lokurkar,Wendy Baur,John J. Castellot,Evan D. Rosen,Bruce M. Spiegelman +12 more
TL;DR: This UCP1-TRAP data set demonstrates striking similarities and important differences between these cell types, including a smooth muscle-like signature expressed by beige, but not classical brown, adipocytes.
Journal ArticleDOI
Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo
Jonathan Z. Long,Daniel K. Nomura,Robert E. Vann,D. Matthew Walentiny,Lamont Booker,Xin Jin,James J. Burston,Laura J. Sim-Selley,Aron H. Lichtman,Jenny L. Wiley,Benjamin F. Cravatt +10 more
TL;DR: A selective and efficacious dual FAAH/MAGL inhibitor is described and it is shown that this agent exhibits broad activity in the tetrad test for CB1 agonism, causing analgesia, hypomotilty, and catalepsy, indicating that AEA and 2-AG signaling pathways interact to regulate specific behavioral processes in vivo, including those relevant to drug abuse.