J
Jordan E. Otto
Researcher at Harvard University
Publications - 5
Citations - 541
Jordan E. Otto is an academic researcher from Harvard University. The author has contributed to research in topics: Chromatin remodeling & Chromatin. The author has an hindex of 3, co-authored 4 publications receiving 284 citations. Previous affiliations of Jordan E. Otto include Broad Institute.
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Journal ArticleDOI
Modular Organization and Assembly of SWI/SNF Family Chromatin Remodeling Complexes
Nazar Mashtalir,Nazar Mashtalir,Andrew R. D’Avino,Andrew R. D’Avino,Brittany C. Michel,Brittany C. Michel,Jie Luo,Joshua Pan,Joshua Pan,Jordan E. Otto,Jordan E. Otto,Hayley J. Zullow,Hayley J. Zullow,Zachary M. McKenzie,Rachel L. Kubiak,Roodolph St. Pierre,Roodolph St. Pierre,Alfredo M. Valencia,Alfredo M. Valencia,Steven J. Poynter,Steven J. Poynter,Seth H. Cassel,Seth H. Cassel,Jeffrey A. Ranish,Cigall Kadoch,Cigall Kadoch +25 more
TL;DR: This work elucidates the architecture and assembly pathway across three classes of mSWI/SNF complexes-canonical BRG1/BRM-associated factor (BAF), polybromo-associated BAF (PBAF, and newly defined ncBAF complexes) and defines the requirement of each subunit for complex formation and stability.
Journal ArticleDOI
ARID1A determines luminal identity and therapeutic response in estrogen-receptor-positive breast cancer.
Guotai Xu,Sagar Chhangawala,Sagar Chhangawala,Emiliano Cocco,Pedram Razavi,Yanyan Cai,Jordan E. Otto,Lorenzo Ferrando,Lorenzo Ferrando,Pier Selenica,Erik Ladewig,Carmen Chan,Arnaud Da Cruz Paula,Matthew Witkin,Yuanming Cheng,Jane Park,Cristian Serna-Tamayo,Cristian Serna-Tamayo,Huiyong Zhao,Fan Wu,Mirna Sallaku,Xuan Qu,Alison Zhao,Clayton K. Collings,Clayton K. Collings,Andrew R. D’Avino,Andrew R. D’Avino,Komal Jhaveri,Richard Koche,Ross L. Levine,Jorge S. Reis-Filho,Cigall Kadoch,Cigall Kadoch,Maurizio Scaltriti,Christina S. Leslie,José Baselga,José Baselga,Eneda Toska +37 more
TL;DR: A CRISPR–CAS9 screen, analysis of patient data, and functional in vivo and in vitro experiments identify a critical role for ARID1A in determining breast luminal cell identity and endocrine therapeutic response in estrogen-receptor-positive breast cancer.
Journal ArticleDOI
A Two-Faced mSWI/SNF Subunit: Dual Roles for ARID1A in Tumor Suppression and Oncogenicity in the Liver
Jordan E. Otto,Cigall Kadoch +1 more
TL;DR: Context-dependent oncogenic and tumor-suppressive functions for the mammalian SWI/SNF (BAF) complex subunit ARID1A in the development and progression of hepatocellular carcinoma (HCC).
Journal ArticleDOI
Structural and functional properties of mSWI/SNF chromatin remodeling complexes revealed through single-cell perturbation screens.
Jordan E. Otto,Oana Ursu,Alexander P. Wu,Evan B. Winter,Michael S. Cuoco,Sai Ma,Kristin Qian,Brittany C. Michel,Jason D. Buenrostro,Bonnie Berger,Aviv Regev,Cigall Kadoch +11 more
TL;DR: In this article , the authors performed Perturb-seq-based CRISPR-Cas9 knockout screens targeting mSWI/SNF subunits individually and in select combinations, followed by single-cell RNA-seq and SHARE-seq.
Posted ContentDOI
Arid1a loss potentiates pancreatic β-cell regeneration through activation of EGF signaling
Cemre Celen,Jen Chieh Chuang,Shunli Shen,Jordan E. Otto,Jordan E. Otto,Clayton K. Collings,Clayton K. Collings,Xin Luo,Lin Li,Yunguan Wang,Zixi Wang,Yuemeng Jia,Xuxu Sun,Ibrahim Nassour,Jiyoung Park,Alexandra L. Ghaben,Tao Wang,Sam C. Wang,Philipp E. Scherer,Cigall Kadoch,Cigall Kadoch,Hao Zhu +21 more
TL;DR: It is shown that the ARID1A mammalian SWI/SNF complex subunit is a critical regulator of β-cell regeneration and was sufficient to protect against diabetes, and chemical inhibition of ERBB or NR4A was able to block increased regeneration associated with Arid1a loss.