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Alfredo M. Valencia
Researcher at Harvard University
Publications - 13
Citations - 1366
Alfredo M. Valencia is an academic researcher from Harvard University. The author has contributed to research in topics: Chromatin & Chromatin remodeling. The author has an hindex of 9, co-authored 11 publications receiving 651 citations. Previous affiliations of Alfredo M. Valencia include Stanford University & Broad Institute.
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Journal ArticleDOI
Modular Organization and Assembly of SWI/SNF Family Chromatin Remodeling Complexes
Nazar Mashtalir,Nazar Mashtalir,Andrew R. D’Avino,Andrew R. D’Avino,Brittany C. Michel,Brittany C. Michel,Jie Luo,Joshua Pan,Joshua Pan,Jordan E. Otto,Jordan E. Otto,Hayley J. Zullow,Hayley J. Zullow,Zachary M. McKenzie,Rachel L. Kubiak,Roodolph St. Pierre,Roodolph St. Pierre,Alfredo M. Valencia,Alfredo M. Valencia,Steven J. Poynter,Steven J. Poynter,Seth H. Cassel,Seth H. Cassel,Jeffrey A. Ranish,Cigall Kadoch,Cigall Kadoch +25 more
TL;DR: This work elucidates the architecture and assembly pathway across three classes of mSWI/SNF complexes-canonical BRG1/BRM-associated factor (BAF), polybromo-associated BAF (PBAF, and newly defined ncBAF complexes) and defines the requirement of each subunit for complex formation and stability.
Journal ArticleDOI
A non-canonical SWI/SNF complex is a synthetic lethal target in cancers driven by BAF complex perturbation
Brittany C. Michel,Brittany C. Michel,Andrew R. D’Avino,Andrew R. D’Avino,Seth H. Cassel,Nazar Mashtalir,Nazar Mashtalir,Zachary M. McKenzie,Matthew J. McBride,Matthew J. McBride,Alfredo M. Valencia,Alfredo M. Valencia,Zhou Qianhe,Michael Bocker,Luis M. Soares,Joshua Pan,Joshua Pan,David Remillard,David Remillard,Caleb A. Lareau,Caleb A. Lareau,Hayley J. Zullow,Nora Fortoul,Nathanael S. Gray,James E. Bradner,James E. Bradner,Ho Man Chan,Cigall Kadoch,Cigall Kadoch +28 more
TL;DR: In this paper, the authors comprehensively mapped complex assemblies on chromatin and found that ncBAF complexes uniquely localize to CTCF sites and promoters, and identified ncCAF subunits as synthetic lethal targets specific to synovial sarcoma and malignant rhabdoid tumours, which both exhibit SMARCB1 subunit perturbation.
Journal ArticleDOI
SMARCB1 is required for widespread BAF complex-mediated activation of enhancers and bivalent promoters
Robert Nakayama,John L. Pulice,John L. Pulice,Alfredo M. Valencia,Matthew J. McBride,Zachary M. McKenzie,Mark A. Gillespie,Wai Lim Ku,Mingxiang Teng,Kairong Cui,Robert T Williams,Seth H. Cassel,He Qing,Christian J Widmer,George D. Demetri,Rafael A. Irizarry,Keji Zhao,Jeffrey A. Ranish,Cigall Kadoch,Cigall Kadoch +19 more
TL;DR: Differential regulation by two distinct mSWI/SNF assemblies, BAF and PBAF complexes, enhancers and promoters, respectively, are demonstrated, suggesting that each complex has distinct functions that are perturbed upon BAF47 loss.
Journal ArticleDOI
Long-term maturation of human cortical organoids matches key early postnatal transitions
Aaron Gordon,Se-Jin Yoon,Stephen Tran,Stephen Tran,Christopher D. Makinson,Jin-Young Park,Jimena Andersen,Alfredo M. Valencia,Steve Horvath,Xinshu Xiao,John R. Huguenard,Sergiu P. Pașca,Daniel H. Geschwind +12 more
TL;DR: Based on genome-wide analysis of the epigenetic clock and transcriptomics, as well as RNA editing, this paper observed that three-dimensional human cortical organoids reach postnatal stages between 250 and 300 days, a timeline paralleling in vivo development.
Journal ArticleDOI
Chromatin regulatory mechanisms and therapeutic opportunities in cancer
TL;DR: Recent progress in understanding of oncogenic mechanisms at each level of chromatin organization and regulation is reviewed, and new strategies towards therapeutic intervention are discussed.