J
José L. Cohen
Researcher at University of Paris
Publications - 95
Citations - 5492
José L. Cohen is an academic researcher from University of Paris. The author has contributed to research in topics: Immune system & Graft-versus-host disease. The author has an hindex of 30, co-authored 84 publications receiving 5060 citations. Previous affiliations of José L. Cohen include Centre national de la recherche scientifique & Pierre-and-Marie-Curie University.
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Journal ArticleDOI
Natural regulatory T cells control the development of atherosclerosis in mice.
Hafid Ait-Oufella,Benoît L. Salomon,Stephane Potteaux,Anna-Karin L. Robertson,Pierre Gourdy,Joffrey Zoll,Régine Merval,Bruno Esposito,José L. Cohen,Sylvain Fisson,Richard A. Flavell,Göran K. Hansson,David Klatzmann,Alain Tedgui,Ziad Mallat +14 more
TL;DR: It is shown that naturally arising CD4+CD25+ regulatory T cells, which actively maintain immunological tolerance to self and nonself antigens, are powerful inhibitors of atherosclerosis in several mouse models.
Journal ArticleDOI
CD4(+)CD25(+) immunoregulatory T Cells: new therapeutics for graft-versus-host disease
TL;DR: It is shown that the few CD4+CD25+ T cells naturally present in the transplant regulate GVHD because their removal from the graft dramatically accelerates this disease.
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Recipient-type specific CD4+CD25+ regulatory T cells favor immune reconstitution and control graft-versus-host disease while maintaining graft-versus-leukemia.
Aurélie Trenado,Frédéric Charlotte,Sylvain Fisson,Micael Yagello,David Klatzmann,Benoît L. Salomon,José L. Cohen +6 more
TL;DR: It is shown that regulatory T cells specific for recipient-type alloantigens control GVHD while favoring immune reconstitution, suggesting that recipient- type specific Treg's could be preferentially used in the control of GV HD in future clinical trials.
Journal ArticleDOI
Bone Marrow Mesenchymal Stem Cells Suppress Lymphocyte Proliferation In Vitro but Fail to Prevent Graft-versus-Host Disease in Mice
Muriel Sudres,Françoise Norol,Aurélie Trenado,Sylvie Grégoire,Frédéric Charlotte,Béatrice Levacher,Jean-Jacques Lataillade,Philippe Bourin,Xavier Holy,Jean-Paul Vernant,David Klatzmann,José L. Cohen +11 more
TL;DR: Experimental data do not support a significant immunosuppressive effect of MSCs in vivo for the treatment of GVHD, a major cause of morbidity and mortality after allogeneic hemopoietic stem cell transplantation.
Journal ArticleDOI
Expansion of CD4+CD25+ regulatory T cells by intravenous immunoglobulin: a critical factor in controlling experimental autoimmune encephalomyelitis.
Amal Ephrem,Souleima Chamat,Catherine Miquel,Sylvain Fisson,Sylvain Fisson,Sylvain Fisson,Luc Mouthon,Giuseppina Caligiuri,Giuseppina Caligiuri,Giuseppina Caligiuri,Sandrine Delignat,Sandrine Delignat,Sandrine Delignat,Sriramulu Elluru,Sriramulu Elluru,Sriramulu Elluru,Jagadeesh Bayry,Jagadeesh Bayry,Jagadeesh Bayry,Sébastien Lacroix-Desmazes,Sébastien Lacroix-Desmazes,Sébastien Lacroix-Desmazes,José L. Cohen,José L. Cohen,Benoît L. Salomon,Benoît L. Salomon,Michel D. Kazatchkine,Michel D. Kazatchkine,Michel D. Kazatchkine,Srini V. Kaveri,Srini V. Kaveri,Srini V. Kaveri,Namita Misra,Namita Misra,Namita Misra +34 more
TL;DR: It is shown that prophylactic infusion of IVIg prevents the development of experimental autoimmune encephalomyelitis (EAE), an accepted animal model for multiple sclerosis (MS), and the protection was Treg-mediated because IVIG failed to protect against EAE in mice that were depleted of the Treg population.