J
Jose Luis Vela
Researcher at La Jolla Institute for Allergy and Immunology
Publications - 28
Citations - 1305
Jose Luis Vela is an academic researcher from La Jolla Institute for Allergy and Immunology. The author has contributed to research in topics: B cell & Receptor editing. The author has an hindex of 17, co-authored 28 publications receiving 1175 citations. Previous affiliations of Jose Luis Vela include University of California, Los Angeles & Scripps Research Institute.
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Journal ArticleDOI
Invariant natural killer T cells recognize glycolipids from pathogenic Gram-positive bacteria
Yuki Kinjo,Petr A. Illarionov,Jose Luis Vela,Bo Pei,Enrico Girardi,Xiangming Li,Yali Li,Masakazu Imamura,Yukihiro Kaneko,Akiko Okawara,Yoshitsugu Miyazaki,Anaximandro Gómez-Velasco,Paul R. Rogers,Samira Dahesh,Satoshi Uchiyama,Archana Khurana,Kazuyoshi Kawahara,Hasan Yesilkaya,Peter W. Andrew,Chi-Huey Wong,Kazuyoshi Kawakami,Victor Nizet,Gurdyal S. Besra,Moriya Tsuji,Dirk M. Zajonc,Mitchell Kronenberg +25 more
TL;DR: The results show how microbial lipids position the sugar for recognition by the invariant TCR and extend the range of microbes recognized by this conserved TCR to several clinically important bacteria.
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Decoration of T-independent antigen with ligands for CD22 and Siglec-G can suppress immunity and induce B cell tolerance in vivo.
Bao Hoa Duong,Hua Tian,Takayuki Ota,Gladys C. Completo,Shoufa Han,Jose Luis Vela,Miyo Ota,Michael Kubitz,Nicolai V. Bovin,James C. Paulson,David Nemazee +10 more
TL;DR: The results support a role for siglecs in B cell self-/nonself-discrimination, namely suppressing responses to self-associated antigens while permitting rapid “missing self”–responses to unsialylated multimeric antIGens.
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HVEM signalling at mucosal barriers provides host defence against pathogenic bacteria
Jr-Wen Shui,Alexandre Larange,Gisen Kim,Jose Luis Vela,Sonja Zahner,Hilde Cheroutre,Mitchell Kronenberg +6 more
TL;DR: HVEM is pinpointed as an important orchestrator of mucosal immunity, integrating signals from innate lymphocytes to induce optimal epithelial Stat3 activation, which indicates that targeting HVEM with agonists could improve host defence.
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Targeted delivery of lipid antigen to macrophages via the CD169/sialoadhesin endocytic pathway induces robust invariant natural killer T cell activation
Norihito Kawasaki,Jose Luis Vela,Corwin M. Nycholat,Christoph Rademacher,Archana Khurana,Nico van Rooijen,Paul R. Crocker,Mitchell Kronenberg,James C. Paulson +8 more
TL;DR: It is shown that targeted delivery of a lipid antigen to CD169+ macrophages in vivo results in robust iNKT cell activation in liver and spleen using nanogram amounts of antigen.
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Basal B Cell Receptor-Directed Phosphatidylinositol 3-Kinase Signaling Turns Off RAGs and Promotes B Cell-Positive Selection
Laurent Verkoczy,Bao Duong,Patrick Skog,Djemel Aït-Azzouzene,Kamal D. Puri,Jose Luis Vela,David Nemazee +6 more
TL;DR: It appears that when the BCR of an immature B cell is ligated, PIP3 levels are reduced, PLCγ2 activation is diminished, and receptor editing is promoted by sustained RAG expression, suggesting PI3K signaling is an important cue required for fostering development of B cells carrying a useful BCR.