Bo Pei

TL;DR: The results show how microbial lipids position the sugar for recognition by the invariant TCR and extend the range of microbes recognized by this conserved TCR to several clinically important bacteria.

TL;DR: House dust contains antigens capable of activating mouse and human iNKT cells, contributing to allergen-induced airway inflammation.

TL;DR: The data indicate that there may be more than one type of self-Ag for iNKT cells, that theSelf-Ags comparing mouse and human may not be conserved, and that the search to identify these molecules should not be confined to GSLs.

TL;DR: There is a great degree of variability in the antigenic potency of different natural Sphingomonas glycolipids, with the C21cycl sphingosine having intermediate potency and the oligosaccharide-containing antigens exhibiting limited or no stimulatory capacity.

TL;DR: It is emphasized that multiple steps, including interactions with the adaptors AP-2 and AP-3, are required for normal trafficking of mCD1d and that these different steps are mediated by only a few cytoplasmic amino acids.