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José Melo-Cristino

Researcher at Instituto de Medicina Molecular

Publications -  150
Citations -  5346

José Melo-Cristino is an academic researcher from Instituto de Medicina Molecular. The author has contributed to research in topics: Serotype & Multilocus sequence typing. The author has an hindex of 39, co-authored 139 publications receiving 4681 citations. Previous affiliations of José Melo-Cristino include University of Lisbon & Universidade Nova de Lisboa.

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Pherotypes are driving genetic differentiation within Streptococcus pneumoniae

TL;DR: Standard population genetic analysis and multilocus infinite allele model simulations support the hypothesis that two genetically differentiated populations are defined by the major pherotypes, and it is shown that pherotype is a clonal property of pneumococci.
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Antimicrobial Resistance in Staphylococci and Enterococci in 10 Portuguese Hospitals in 1996 and 1997

TL;DR: This survey showed that resistance profiles of staphylococci and enterococci hospital isolates have not changed in the last 5 years in Portugal, with the exception of the rise in vancomycin resistance in E. faecium.
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Changes in Streptococcus pyogenes causing invasive disease in Portugal: evidence for superantigen gene loss and acquisition.

TL;DR: An ongoing genomic diversification of GAS invasive isolates in Portugal may contribute to the persistence of clones with improved fitness or virulence, as indicated by both PFGE profiling and emm typing.
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Scarlet fever is caused by a limited number of Streptococcus pyogenes lineages and is associated with the exotoxin genes ssa, speA and speC.

TL;DR: In this article, a strict association between scarlet fever and these exotoxins is found, but no evidence of a link between the exotoxin and the scarlet virus was established.
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Serotype changes in adult invasive pneumococcal infections in Portugal did not reduce the high fraction of potentially vaccine preventable infections

TL;DR: The serotype and antimicrobial susceptibility of 1100 isolates responsible for adult invasive pneumococcal infections (IPD) in Portugal between 2006 and 2008 were determined and showed a continued decline of the serotypes included in the 7-valent conjugate vaccine (PCV7) in adult IPD and a rise of serotypes including in the 13-valents conjugated vaccine, increasing its potential coverage of adult I PD to 70% in 2008.