J
José Melo-Cristino
Researcher at Instituto de Medicina Molecular
Publications - 150
Citations - 5346
José Melo-Cristino is an academic researcher from Instituto de Medicina Molecular. The author has contributed to research in topics: Serotype & Multilocus sequence typing. The author has an hindex of 39, co-authored 139 publications receiving 4681 citations. Previous affiliations of José Melo-Cristino include University of Lisbon & Universidade Nova de Lisboa.
Papers
More filters
Journal ArticleDOI
First description of colistin and tigecycline-resistant acinetobacter baumannii producing KPC-3 carbapenemase in Portugal
Cátia Caneiras,Filipa Calisto,Gabriela Jorge Da Silva,Luís Lito,José Melo-Cristino,Aida Duarte +5 more
TL;DR: The molecular screening led to the first identification of the A. baumannii KPC-3 producer in Portugal with a full antimicrobial resistance profile including tigecycline and colistin.
Journal ArticleDOI
Vitamin D-related polymorphisms and vitamin D levels as risk biomarkers of COVID-19 disease severity.
Ana T. Freitas,Conceição Calhau,Gonçalo Antunes,Beatriz Araújo,Matilde Bandeira,Sofia Barreira,Filipa Bazenga,Sandra Braz,Daniel Caldeira,Susana Constantino Rosa Santos,Ana Faria,Daniel Faria,Marta Fraga,Beatriz Nogueira-Garcia,Lúcia Gonçalves,Pavlo Kovalchuk,Luísa Lacerda,Hugo Lopes,Daniel Luís,Fábio Medeiros,Ana M. P. Melo,José Melo-Cristino,Ana C. Miranda,Clara Pereira,Ana Teresa Pinto,João L. Pinto,Helena Proença,Angélica Ramos,João P. R. Rato,Filipe Rocha,Júlio César Rocha,André Moreira-Rosário,Helena Vazão,Yuliya Volovetska,João Tiago Guimarães,Fausto J. Pinto +35 more
TL;DR: In this paper, the impact of the genetic background related to vitamin D pathways on COVID-19 severity was investigated, and the results showed that polymorphisms in the vitamin D binding protein encoded by the GC gene are related to the infection severity.
Journal ArticleDOI
Capsule impairs efficient adherence of Streptococcus agalactiae to intestinal epithelium in tilapias Oreochromis sp
Paola Barato,E. R. Martins,Gersson Vasquez,Mário Ramirez,José Melo-Cristino,N. Martínez,Carlos Iregui +6 more
TL;DR: It is suggested that the capsule impairs the adhesion of S. agalactiae to tilapia intestine and that the acidic milieu could regulate adherence of encapsulated strains.
Journal ArticleDOI
Declining macrolide resistance in Streptococcus pyogenes in Portugal (2007–13) was accompanied by continuous clonal changes
TL;DR: The continuous decline in macrolide resistance detected since 2000, accompanied by a high clonal instability, emphasizes the importance of considering factors other than antibiotic consumption in explaining the prevalence of macrolid-resistant GAS.
Journal ArticleDOI
In vitro activity of ceftolozane-tazobactam against Enterobacterales and Pseudomonas aeruginosa causing urinary, intra-abdominal and lower respiratory tract infections in intensive care units in Portugal: The STEP multicenter study
Sergio García-Fernández,María García-Castillo,José Melo-Cristino,Margarida F Pinto,Elsa Gonçalves,Valquíria Alves,Ana Raquel Vieira,Elmano Ramalheira,Luísa Sancho,José Diogo,Rui Seabra Ferreira,Daniela A. Fossato da Silva,Catarina Chaves,Leonor Pássaro,Laura Paixão,Rafael Cantón +15 more
TL;DR: These microbiological results reinforce ceftolozane-tazobactam as a therapeutic option in ICU patients with UTI, IAI or LRTI due to P. aeruginosa or Enterobacterales isolates, but not for carbapenemase producers.