J
José Melo-Cristino
Researcher at Instituto de Medicina Molecular
Publications - 150
Citations - 5346
José Melo-Cristino is an academic researcher from Instituto de Medicina Molecular. The author has contributed to research in topics: Serotype & Multilocus sequence typing. The author has an hindex of 39, co-authored 139 publications receiving 4681 citations. Previous affiliations of José Melo-Cristino include University of Lisbon & Universidade Nova de Lisboa.
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Journal ArticleDOI
The presence of the pilus locus is a clonal property among pneumococcal invasive isolates.
TL;DR: The pilus islet is present in a minority of pneumococcal isolates recovered from human invasive infections and is therefore not an essential virulence factor in these infections.
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Wound healing potential of topical bacteriophage therapy on diabetic cutaneous wounds
João J. Mendes,Rodrigues Leandro Clara Isabel,Volker Côrte-Real Sofia,Raquel Barbosa,Patrícia Cavaco-Silva,José Melo-Cristino,Andrzej Górski,Miguel Garcia +7 more
TL;DR: The results suggest that topically administered bacteriophage treatment may be effective in resolving chronic infections, especially when applied in conjunction with wound debridement, and have important implications for the feasibility of using topical antimicrobial therapies to safely treat chronic infections in diabetes mellitus patients.
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Serotypes 1, 7F and 19A became the leading causes of pediatric invasive pneumococcal infections in Portugal after 7 years of heptavalent conjugate vaccine use.
TL;DR: This study showed a continued decline of PCV7 serotypes and that overall resistance has stabilized following the initial decline of the first post-PCV7 years, and non-vaccine serotypes are emerging as important causes of IPD.
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Changes in Streptococcus pneumoniae serotypes causing invasive disease with non-universal vaccination coverage of the seven-valent conjugate vaccine.
TL;DR: PCV7 use with coverage of 43% of children with four doses in the 2004 birth cohort, although substantially below universal coverage, seems to have contributed to greatly reducing the proportion of invasive infections due to vaccine serotypes 4, 6B, 14 and 23F.
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Extensive Dissemination of Methicillin-Resistant Staphylococcus aureus (MRSA) between the Hospital and the Community in a Country with a High Prevalence of Nosocomial MRSA
Diana Espadinha,Nuno A. Faria,Maria Miragaia,Luís Lito,José Melo-Cristino,Hermínia de Lencastre +5 more
TL;DR: The emergence and spread of EMRSA-15 may be associated to the observed increase in MRSA frequency in the hospital and the consequent spillover of MRSA into the community.