J
Josée Guirouilh-Barbat
Researcher at University of Paris
Publications - 7
Citations - 222
Josée Guirouilh-Barbat is an academic researcher from University of Paris. The author has contributed to research in topics: Homologous recombination & DNA repair. The author has an hindex of 4, co-authored 7 publications receiving 163 citations. Previous affiliations of Josée Guirouilh-Barbat include Institut Gustave Roussy.
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Journal Article
Initiation of DNA double strand break repair: signaling and single-stranded resection dictate the choice between homologous recombination, non-homologous end-joining and alternative end-joining
TL;DR: The main DSB repair mechanisms are presented and the importance of the fine tuning of this network for genome stability maintenance and for tumor protection in fine is discussed.
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RhoB promotes γH2AX dephosphorylation and DNA double-strand break repair.
Kenza Mamouni,Kenza Mamouni,Agnese Cristini,Agnese Cristini,Josée Guirouilh-Barbat,Sylvie Monferran,Sylvie Monferran,Anthony Lemarié,Anthony Lemarié,Jean Charles Faye,Bernard S. Lopez,Gilles Favre,Gilles Favre,Olivier Sordet +13 more
TL;DR: It is proposed that DSBs activate a Chk2-HuR-RhoB pathway that promotes PP2A-mediated dephosphorylation of γH2AX and DSB repair, and that RhoB loss increases DSB-mediated genomic instability and tumor progression.
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Role of the double-strand break repair pathway in the maintenance of genomic stability
TL;DR: The molecular mechanisms involved in HR and NHEJ and the recently described alternative end-joining mechanism, which is exclusively mutagenic, are presented.
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Targeting acute myeloid leukemia dependency on VCP-mediated DNA repair through a selective second-generation small-molecule inhibitor
Blandine Roux,Camille Vaganay,Jesse D. Vargas,Gabriela Alexe,Gabriela Alexe,Chaïma Benaksas,Bryann Pardieu,Nina Fenouille,Jana M. Ellegast,Jana M. Ellegast,Edyta Malolepsza,Frank Ling,Gaetano Sodaro,Linda Ross,Linda Ross,Yana Pikman,Yana Pikman,Amy Saur Conway,Amy Saur Conway,Yangzhong Tang,Tony Wu,Daniel Anderson,Ronan Le Moigne,Han-Jie Zhou,Frederic Luciano,Christina R. Hartigan,Ilene Galinsky,Daniel J. DeAngelo,Richard Stone,Patrick Auberger,Monica Schenone,Steven A. Carr,Josée Guirouilh-Barbat,Bernard S. Lopez,Mehdi Khaled,Kasper Lage,Olivier Hermine,Michael T. Hemann,Alexandre Puissant,Kimberly Stegmaier,Kimberly Stegmaier,Lina Benajiba +41 more
TL;DR: In this paper, the authors identified the AAA-ATPase valosin-containing protein (VCP) as a top stress-related vulnerability in acute myeloid leukemia (AML).
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Combining Homologous Recombination and Phosphopeptide-binding Data to Predict the Impact of BRCA1 BRCT Variants on Cancer Risk.
Ambre Petitalot,Ambre Petitalot,Elodie Dardillac,Eric Jacquet,Naïma Nhiri,Josée Guirouilh-Barbat,Patrick Julien,Isslam Bouazzaoui,Dorine Bonte,Jean Feunteun,Jeff A. Schnell,Philippe Lafitte,Jean-Christophe Aude,Catherine Noguès,Etienne Rouleau,Rosette Lidereau,Bernard S. Lopez,Sophie Zinn-Justin,Sandrine M. Caputo +18 more
TL;DR: The data suggest that HR-defective variants, which present, in addition, BRCT domains either insoluble in bacteria or defective for phosphopeptide binding, lead to an increased cancer risk.