J
Joseph Bradley
Researcher at Washington University in St. Louis
Publications - 38
Citations - 977
Joseph Bradley is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Genome-wide association study & Medicine. The author has an hindex of 10, co-authored 33 publications receiving 712 citations. Previous affiliations of Joseph Bradley include University of Kansas & University of Washington.
Papers
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Journal ArticleDOI
Severity of Respiratory Syncytial Virus Bronchiolitis Is Affected by Cigarette Smoke Exposure and Atopy
Joseph Bradley,Leonard B. Bacharier,JoAnn Bonfiglio,Kenneth B. Schechtman,Robert C. Strunk,Gregory A. Storch,Mario Castro +6 more
TL;DR: The severity of RSV bronchiolitis early in life seems modified by postnatal maternal cigarette smoke exposure and atopy and age of the infant, not by levels of allergens in the home environment, although 25% of households had elevated allergen levels.
Journal ArticleDOI
Asthma Intervention Program Prevents Readmissions in High Healthcare Users
Mario Castro,Nina A. Zimmermann,Sue Crocker,Joseph Bradley,Charles Leven,Kenneth B. Schechtman +5 more
TL;DR: A brief intervention program focusing on high healthcare users with asthma can result in improved asthma control and reduced hospital use with substantial cost savings.
Journal ArticleDOI
The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer's disease risk
Yuetiva Deming,Yuetiva Deming,Fabia Filipello,Francesca Cignarella,Claudia Cantoni,Simon Hsu,Robert J. Mikesell,Zeran Li,Jorge L. Del-Aguila,Umber Dube,Fabiana Geraldo Farias,Joseph Bradley,John P. Budde,Laura Ibanez,Maria Victoria Fernandez,Kaj Blennow,Kaj Blennow,Henrik Zetterberg,Henrik Zetterberg,Henrik Zetterberg,Amanda Heslegrave,Per Johansson,Johan Svensson,Bengt Nellgård,Alberto Lleó,Daniel Alcolea,Jordi Clarimón,Lorena Rami,Jose Luis Molinuevo,Marc Suárez-Calvet,Marc Suárez-Calvet,Estrella Morenas-Rodríguez,Gernot Kleinberger,Michael Ewers,Oscar Harari,Christian Haass,Christian Haass,Tom J. Brett,Bruno A. Benitez,Celeste M. Karch,Laura Piccio,Laura Piccio,Carlos Cruchaga +42 more
TL;DR: Two independent genetic associations in the membrane-spanning 4-domains subfamily A (MS4A) gene region suggest that MS4A4A modulates sTREM2 and indicate that TREM2 may be involved in AD pathogenesis not only in T REM2 risk-variant carriers but also in those with sporadic disease.
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A single-nuclei RNA sequencing study of Mendelian and sporadic AD in the human brain
Jorge L. Del-Aguila,Zeran Li,Umber Dube,Kathie A. Mihindukulasuriya,John P. Budde,Maria Victoria Fernandez,Laura Ibanez,Joseph Bradley,Fengxian Wang,Kristy Bergmann,Richard Davenport,John Morris,Holtzman David M,Richard J. Perrin,Bruno A. Benitez,Joseph D. Dougherty,Carlos Cruchaga,Oscar Harari +17 more
TL;DR: A collection of best practices is proposed to generate a highly detailed molecular cell atlas of highly informative frozen tissue stored in brain banks and whether single-nuclei RNA-seq from the human brains recapitulate the expression profile of disease-associated microglia discovered in mouse models.
Journal ArticleDOI
Asthma Exacerbations after Glucocorticoid Withdrawal Reflects T Cell Recruitment to the Airway
Mario Castro,Sharon R. Bloch,Michelle V. Jenkerson,Steve DeMartino,Daniel L. Hamilos,Rebecca B. Cochran,Xueping E. Liang Zhang,Haochuan Wang,Joseph Bradley,Kenneth B. Schechtman,Michael J. Holtzman +10 more
TL;DR: The pattern of glucocorticoid-sensitive inflammation during an asthma exacerbation is more reminiscent of an antiviral response than an eosinophil-predominant response to allergen and implies an independent role for airway T cells in mediating asthma flares and in determining glucoc Corticoid efficacy in the treatment of this disease.