L
Laura Ibanez
Researcher at Washington University in St. Louis
Publications - 67
Citations - 1947
Laura Ibanez is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Genome-wide association study & Medicine. The author has an hindex of 15, co-authored 54 publications receiving 1164 citations. Previous affiliations of Laura Ibanez include University of Washington.
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Journal ArticleDOI
A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease.
Kuan-lin Huang,Edoardo Marcora,Anna A. Pimenova,Antonio Fabio Di Narzo,Manav Kapoor,Sheng Chih Jin,Oscar Harari,Sarah Bertelsen,Benjamin P. Fairfax,Jake Czajkowski,Vincent Chouraki,Benjamin Grenier-Boley,Benjamin Grenier-Boley,Céline Bellenguez,Céline Bellenguez,Yuetiva Deming,Andrew M. McKenzie,Towfique Raj,Alan E. Renton,John P. Budde,Albert V. Smith,Annette L. Fitzpatrick,Joshua C. Bis,Anita L. DeStefano,Hieab H.H. Adams,M. Arfan Ikram,Sven J. van der Lee,Jorge L. Del-Aguila,Maria Victoria Fernandez,Laura Ibanez,Rebecca Sims,Valentina Escott-Price,Richard Mayeux,Jonathan L. Haines,Lindsay A. Farrer,Lindsay A. Farrer,Margaret A. Pericak-Vance,Jean-Charles Lambert,Jean-Charles Lambert,Cornelia M. van Duijn,Lenore J. Launer,Sudha Seshadri,Julie Williams,Philippe Amouyel,Philippe Amouyel,Gerard D. Schellenberg,Bin Zhang,Ingrid B. Borecki,John S. K. Kauwe,Carlos Cruchaga,Ke Hao,Alison Goate +51 more
TL;DR: Results suggest that lower SPI1 expression reduces AD risk by regulating myeloid gene expression and cell function, and experimentally altered PU.1 levels affected the expression of mouse orthologs of many AD risk genes and the phagocytic activity of mouse microglial cells.
Journal ArticleDOI
An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations.
Umber Dube,Jorge L. Del-Aguila,Zeran Li,John P. Budde,Shan Jiang,Simon Hsu,Laura Ibanez,Maria Victoria Fernandez,Fabiana H.G. Farias,Joanne Norton,Jen Gentsch,Fengxian Wang,Stephen Salloway,Colin L. Masters,Jae-Hong Lee,Neill R. Graff-Radford,Jasmeer P. Chhatwal,Randall J. Bateman,John C. Morris,Celeste M. Karch,Oscar Harari,Carlos Cruchaga +21 more
TL;DR: An atlas of human brain circular RNA (circRNA) expression in individuals with and without Alzheimer disease (AD) is generated and circRNA expression correlates with AD severity, even before substantial clinical symptom onset.
Journal ArticleDOI
HIV-associated neurocognitive disorders
Montserrat Sanmarti,Laura Ibanez,Sonia Huertas,Dolors Badenes,David Dalmau,Mark Slevin,Jerzy Krupinski,Aurel Popa-Wagner,Ángeles Jaén +8 more
TL;DR: Standardization and homogenization of neurocognitive tests as well as normalizing and simplification of easily accessible tools that can identify patients with increased risk of cognitive impairment represent an urgent requirement.
Journal ArticleDOI
The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer's disease risk
Yuetiva Deming,Yuetiva Deming,Fabia Filipello,Francesca Cignarella,Claudia Cantoni,Simon Hsu,Robert J. Mikesell,Zeran Li,Jorge L. Del-Aguila,Umber Dube,Fabiana Geraldo Farias,Joseph Bradley,John P. Budde,Laura Ibanez,Maria Victoria Fernandez,Kaj Blennow,Kaj Blennow,Henrik Zetterberg,Henrik Zetterberg,Henrik Zetterberg,Amanda Heslegrave,Per Johansson,Johan Svensson,Bengt Nellgård,Alberto Lleó,Daniel Alcolea,Jordi Clarimón,Lorena Rami,Jose Luis Molinuevo,Marc Suárez-Calvet,Marc Suárez-Calvet,Estrella Morenas-Rodríguez,Gernot Kleinberger,Michael Ewers,Oscar Harari,Christian Haass,Christian Haass,Tom J. Brett,Bruno A. Benitez,Celeste M. Karch,Laura Piccio,Laura Piccio,Carlos Cruchaga +42 more
TL;DR: Two independent genetic associations in the membrane-spanning 4-domains subfamily A (MS4A) gene region suggest that MS4A4A modulates sTREM2 and indicate that TREM2 may be involved in AD pathogenesis not only in T REM2 risk-variant carriers but also in those with sporadic disease.
Journal ArticleDOI
A single-nuclei RNA sequencing study of Mendelian and sporadic AD in the human brain
Jorge L. Del-Aguila,Zeran Li,Umber Dube,Kathie A. Mihindukulasuriya,John P. Budde,Maria Victoria Fernandez,Laura Ibanez,Joseph Bradley,Fengxian Wang,Kristy Bergmann,Richard Davenport,John Morris,Holtzman David M,Richard J. Perrin,Bruno A. Benitez,Joseph D. Dougherty,Carlos Cruchaga,Oscar Harari +17 more
TL;DR: A collection of best practices is proposed to generate a highly detailed molecular cell atlas of highly informative frozen tissue stored in brain banks and whether single-nuclei RNA-seq from the human brains recapitulate the expression profile of disease-associated microglia discovered in mouse models.