J
Joseph Ghika
Researcher at University Hospital of Lausanne
Publications - 77
Citations - 3730
Joseph Ghika is an academic researcher from University Hospital of Lausanne. The author has contributed to research in topics: Stroke & Parkinsonism. The author has an hindex of 28, co-authored 74 publications receiving 3502 citations. Previous affiliations of Joseph Ghika include university of lille & University of Lausanne.
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Journal ArticleDOI
VPS35 Mutations in Parkinson Disease
Carles Vilariño-Güell,Christian Wider,Owen A. Ross,Justus C. Dachsel,Jennifer M. Kachergus,Sarah Lincoln,Alexandra I. Soto-Ortolaza,Stephanie A. Cobb,Greggory J. Wilhoite,Justin A. Bacon,Behrouz Bahareh Behrouz,Heather L. Melrose,Emna Hentati,Andreas Puschmann,Andreas Puschmann,Daniel M. Evans,Elizabeth Conibear,Wyeth W. Wasserman,Jan O. Aasly,Pierre R. Burkhard,Ruth Djaldetti,Joseph Ghika,Fayçal Hentati,Anna Krygowska-Wajs,Timothy Lynch,Timothy Lynch,Eldad Melamed,Alex Rajput,Ali H. Rajput,Alessandra Solida,Ruey-Meei Wu,Ryan J. Uitti,Zbigniew K. Wszolek,François Vingerhoets,Matthew J. Farrer,Matthew J. Farrer +35 more
TL;DR: This study implicates disruption of VPS35 and retromer-mediated trans-membrane protein sorting, rescue, and recycling in the neurodegenerative process leading to PD.
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Strokes restricted to the insular cortex
TL;DR: Strokes restricted to the posterior insula may present with pseudothalamic sensory and vestibular-like syndromes as prominent clinical manifestations, but also dysarthria and aphasia and somatoparaphrenia, and gustatory dysfunction and blood pressure with hypertensive episodes in right lesions.
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White Matter Changes on CT and MRI: An Overview of Visual Rating Scales
P. Scheltens,T. Erkinjunti,Didier Leys,L-O Wahlund,Domenico Inzitari,T. Del Ser,Florence Pasquier,Frederik Barkhof,R Mäntylä,John V. Bowler,Åsa K. Wallin,Joseph Ghika,Franz Fazekas,Leonardo Pantoni +13 more
TL;DR: The development of the NINDS-AIREN criteria for vascular dementia have introduced a new application for these rating scales in investigating and delineating the amount of white matter changes on CT/MRI sufficient to fulfill the criteria.
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Efficiency and safety of bilateral contemporaneous pallidal stimulation (deep brain stimulation) in levodopa-responsive patients with Parkinson's disease with severe motor fluctuations: a 2-year follow-up review
TL;DR: Bilateral pallidal DBS is safe and efficient in patients who have levodopa-responsive parkinsonism with severe fluctuations, and major improvements in motor score, ADL score, and off time persisted beyond 2 years after the operation, but signs of decreased efficacy started to be seen after 12 months.
Journal ArticleDOI
Hyperkinetic movement disorders during and after acute stroke: The Lausanne Stroke Registry
TL;DR: Hyperkinetic movement disorders are uncommon in acute stroke, the commonest types being hemichorea-hemiballism and hemidystonia.