Greggory J. Wilhoite

TL;DR: This study implicates disruption of VPS35 and retromer-mediated trans-membrane protein sorting, rescue, and recycling in the neurodegenerative process leading to PD.

TL;DR: Screening in Parkinson's disease patients from under-represented populations will increase the understanding of the role of LRRK2 variants in disease risk worldwide and suggest that this variant likely originated in an Amerindian population.

TL;DR: This study investigated the frequency of common LRRK2 variants by complete exon sequencing in a series of publicly available African American Parkinson's disease patients and identified three novel synonymous exonic variants and 13 known coding variations; however, there did not appear to be any frequent pathogenic mutations.