H
Heather L. Melrose
Researcher at Mayo Clinic
Publications - 48
Citations - 5816
Heather L. Melrose is an academic researcher from Mayo Clinic. The author has contributed to research in topics: LRRK2 & Parkinson's disease. The author has an hindex of 32, co-authored 48 publications receiving 5118 citations. Previous affiliations of Heather L. Melrose include Medical Research Council & Pfizer.
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Journal ArticleDOI
Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein.
Jada Lewis,Eileen McGowan,Julia Rockwood,Heather L. Melrose,Parimala Nacharaju,Marjon Van Slegtenhorst,Katrina Gwinn-Hardy,Michael P. Murphy,Matt Baker,Xin Yu,Karen Duff,John Hardy,Anthony Corral,Wen Lang Lin,Shu Hui Yen,Dennis W. Dickson,Peter Davies,Mike Hutton +17 more
TL;DR: The phenotype of mice expressing P301L mutant tau mimics features of human tauopathies and provides a model for investigating the pathogenesis of diseases with NFT.
Journal ArticleDOI
VPS35 Mutations in Parkinson Disease
Carles Vilariño-Güell,Christian Wider,Owen A. Ross,Justus C. Dachsel,Jennifer M. Kachergus,Sarah Lincoln,Alexandra I. Soto-Ortolaza,Stephanie A. Cobb,Greggory J. Wilhoite,Justin A. Bacon,Behrouz Bahareh Behrouz,Heather L. Melrose,Emna Hentati,Andreas Puschmann,Andreas Puschmann,Daniel M. Evans,Elizabeth Conibear,Wyeth W. Wasserman,Jan O. Aasly,Pierre R. Burkhard,Ruth Djaldetti,Joseph Ghika,Fayçal Hentati,Anna Krygowska-Wajs,Timothy Lynch,Timothy Lynch,Eldad Melamed,Alex Rajput,Ali H. Rajput,Alessandra Solida,Ruey-Meei Wu,Ryan J. Uitti,Zbigniew K. Wszolek,François Vingerhoets,Matthew J. Farrer,Matthew J. Farrer +35 more
TL;DR: This study implicates disruption of VPS35 and retromer-mediated trans-membrane protein sorting, rescue, and recycling in the neurodegenerative process leading to PD.
Journal ArticleDOI
Identification of the α2-δ-1 subunit of voltage-dependent calcium channels as a molecular target for pain mediating the analgesic actions of pregabalin
Mark J. Field,Peter J. Cox,Emma Stott,Heather L. Melrose,Heather L. Melrose,James Offord,Ti-Zhi Su,Steve Bramwell,Laura Corradini,Steven England,Joanna S Winks,Ross A. Kinloch,Jan Hendrich,Annette C. Dolphin,Tony Webb,Dic Williams +15 more
TL;DR: It is shown conclusively that the analgesic actions of pregabalin are mediated through the α2-δ-1 subunit of voltage-gated calcium channels and establish this subunit as a therapeutic target for pain control.
Journal ArticleDOI
Translation initiator EIF4G1 mutations in familial Parkinson disease
Marie-Christine Chartier-Harlin,Marie-Christine Chartier-Harlin,Justus C. Dachsel,Carles Vilariño-Güell,Sarah Lincoln,Frédéric Leprêtre,Frédéric Leprêtre,Mary M. Hulihan,Jennifer M. Kachergus,Austen J. Milnerwood,Lucia Tapia,Mee Sook Song,Emilie Le Rhun,Eugénie Mutez,Eugénie Mutez,Lydie Larvor,Lydie Larvor,A. Duflot,A. Duflot,Christel Vanbesien-Mailliot,Christel Vanbesien-Mailliot,Alexandre Kreisler,Alexandre Kreisler,Owen A. Ross,Kenya Nishioka,Alexandra I. Soto-Ortolaza,Stephanie A. Cobb,Heather L. Melrose,Bahareh Behrouz,Brett H. Keeling,Justin A. Bacon,Emna Hentati,Lindsey N. Williams,Akiko Yanagiya,Nahum Sonenberg,Paul J. Lockhart,Abba C. Zubair,Ryan J. Uitti,Jan O. Aasly,Anna Krygowska-Wajs,Grzegorz Opala,Zbigniew K. Wszolek,Roberta Frigerio,Demetrius M. Maraganore,David Gosal,Timothy Lynch,Michael Hutchinson,Anna Rita Bentivoglio,Enza Maria Valente,Enza Maria Valente,William C. Nichols,Nathan Pankratz,Tatiana Foroud,Rachel A. Gibson,Fayçal Hentati,Dennis W. Dickson,Alain Destée,Alain Destée,Matthew J. Farrer,Matthew J. Farrer +59 more
TL;DR: Genome-wide analysis of a multi-incident family with autosomal-dominant parkinsonism has implicated a locus on chromosomal region 3q26-q28 and highlighted a convergent pathway for monogenic, toxin and perhaps virally-induced Parkinson disease.
Journal ArticleDOI
Impaired dopaminergic neurotransmission and microtubule-associated protein tau alterations in human LRRK2 transgenic mice.
Heather L. Melrose,Justus C. Dachsel,Bahareh Behrouz,Sarah Lincoln,Mei Yue,Kelly M. Hinkle,Caroline Kent,Elena Korvatska,John-Paul Taylor,L. Witten,Y. Q. Liang,Joel E. Beevers,Mona Boules,Brittany N. Dugger,V. A. Serna,A. Gaukhman,Xin Yu,Monica Castanedes-Casey,Adam Braithwaite,S. Ogholikhan,N. Yu,David I. Bass,G. Tyndall,Gerard D. Schellenberg,Dennis W. Dickson,Christopher Janus,Matthew J. Farrer +26 more
TL;DR: It is hypothesized that LRRk2 may impact on tau processing which subsequently leads to increased phosphorylation, which suggests that other post-translational modifications of tau occur in G2019S mice.