J
Joshua N. Burton
Researcher at University of Washington
Publications - 29
Citations - 4711
Joshua N. Burton is an academic researcher from University of Washington. The author has contributed to research in topics: Genome & Sequence assembly. The author has an hindex of 16, co-authored 29 publications receiving 3946 citations. Previous affiliations of Joshua N. Burton include University of Manchester & University of Utah.
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Journal ArticleDOI
Accurate identification of centromere locations in yeast genomes using Hi-C
Nelle Varoquaux,Ivan Liachko,Ferhat Ay,Joshua N. Burton,Jay Shendure,Maitreya J. Dunham,Jean-Philippe Vert,William Stafford Noble +7 more
TL;DR: A method is described, Centurion, that jointly infers the locations of all centromeres in a single genome from Hi-C data by exploiting the centromres’ tendency to cluster in three-dimensional space and is shown to be robust in datasets with low sequencing depth.
Journal ArticleDOI
The Rhododendron Genome and Chromosomal Organization Provide Insight into Shared Whole-Genome Duplications across the Heath Family (Ericaceae)
Valerie L. Soza,Dale Lindsley,Adam Waalkes,Elizabeth Ramage,Rupali P Patwardhan,Joshua N. Burton,Andrew Adey,Andrew Adey,Akash Kumar,Akash Kumar,Ruolan Qiu,Jay Shendure,Benjamin D. Hall +12 more
TL;DR: The chromosome-scale de novo assembly and genome annotation of Rhododendron williamsianum is reported as a basis for continued study of this large genus of >1,000 species and finds evidence for two shared, ancient WGDs in Rhododendedron and Vaccinium members that predate the Ericaceae family and, in one case, the Ericales order.
Journal ArticleDOI
Identification of a novel interspecific hybrid yeast from a metagenomic spontaneously inoculated beer sample using Hi-C.
Caiti Smukowski Heil,Joshua N. Burton,Ivan Liachko,Anne Friedrich,Noah A. Hanson,Cody L. Morris,Joseph Schacherer,Jay Shendure,Jay Shendure,James H. Thomas,Maitreya J. Dunham +10 more
TL;DR: This work shows that Hi‐C‐based metagenomic methods can overcome the limitation of traditional sequencing methods in studying complex mixtures of genomes.
Journal ArticleDOI
Simultaneous digital quantification and fluorescence-based size characterization of massively parallel sequencing libraries.
Matthew T. Laurie,Jessica A. Bertout,Sean D. Taylor,Joshua N. Burton,Jay Shendure,Jason H. Bielas +5 more
TL;DR: This work proposes and test an alternative method for quality control of sequencing libraries using droplet digital PCR (ddPCR), and achieves the joint quantification and size determination of target DNA with a single ddPCR assay.
Posted ContentDOI
Single-molecule sequencing and conformational capture enable de novo mammalian reference genomes
Derek M. Bickhart,Benjamin D. Rosen,Sergey Koren,B.L. Sayre,Alex Hastie,Saki Chan,Joyce Lee,Ernest T. Lam,Ivan Liachko,Shawn T. Sullivan,Joshua N. Burton,Heather J. Huson,Christy M. Kelley,J.L. Hutchison,Yang Zhou,Yang Zhou,Jiajie Sun,Alessandra Crisà,F. Abel Ponce de León,John C. Schwartz,John A. Hammond,Geoffrey C. Waldbieser,Steven G. Schroeder,George E. Liu,Maitreya J. Dunham,Jay Shendure,Tad S. Sonstegard,Adam M. Phillippy,Curtis P. Van Tassell,Timothy P L Smith +29 more
TL;DR: This assembly represents a >250-fold improvement in contiguity compared to the previously published C. hircus assembly, and better resolves repetitive structures longer than 1 kb, supporting the most complete repeat family and immune gene complex representation ever produced for a ruminant species.