J
Joshua R. Cook
Researcher at Columbia University
Publications - 14
Citations - 3865
Joshua R. Cook is an academic researcher from Columbia University. The author has contributed to research in topics: Insulin & Lipogenesis. The author has an hindex of 10, co-authored 10 publications receiving 1841 citations. Previous affiliations of Joshua R. Cook include University of Cambridge.
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Journal ArticleDOI
Post-acute COVID-19 syndrome.
Ani Nalbandian,Kartik Sehgal,Kartik Sehgal,Aakriti Gupta,Aakriti Gupta,Mahesh V. Madhavan,Claire McGroder,Jacob S. Stevens,Joshua R. Cook,Anna S. Nordvig,Daniel Shalev,Tejasav S. Sehrawat,Neha Ahluwalia,Behnood Bikdeli,Donald Dietz,Caroline Der-Nigoghossian,Nadia Liyanage-Don,Gregg F. Rosner,Elana J. Bernstein,Sumit Mohan,Akinpelumi A Beckley,David S. Seres,Toni K. Choueiri,Toni K. Choueiri,Nir Uriel,John C. Ausiello,Domenico Accili,Daniel E. Freedberg,Matthew R. Baldwin,Allan Schwartz,Daniel Brodie,Christine Kim Garcia,Mitchell S.V. Elkind,Jean M. Connors,Jean M. Connors,John P. Bilezikian,Donald W. Landry,Elaine Wan +37 more
TL;DR: A comprehensive review of the current literature on post-acute COVID-19, its pathophysiology and its organ-specific sequelae is provided in this paper, where the authors discuss relevant considerations for the multidisciplinary care of COPD survivors and propose a framework for the identification of those at high risk for COPD and their coordinated management through dedicated COPD clinics.
Journal ArticleDOI
TAC3 and TACR3 mutations in familial hypogonadotropic hypogonadism reveal a key role for Neurokinin B in the central control of reproduction
A. Kemal Topaloglu,Frank Reimann,Metin Guclu,Ayse Serap Yalin,L. Damla Kotan,Keith M. Porter,Ayşe Serin,Neslihan Önenli Mungan,Joshua R. Cook,Mehmet Nuri Ozbek,Sazi Imamoglu,N Sema Akalin,Bilgin Yüksel,Stephen O'Rahilly,Robert K. Semple +14 more
TL;DR: Findings implicate Neurokinin B as a critical central regulator of human gonadal function and suggest new approaches to the pharmacological control of human reproduction and sex hormone-related diseases.
Journal ArticleDOI
Integrated control of hepatic lipogenesis versus glucose production requires FoxO transcription factors.
Rebecca A. Haeusler,Kirsten Hartil,Bhavapriya Vaitheesvaran,Isabel Arrieta-Cruz,Colette M. Knight,Joshua R. Cook,Helene L. Kammoun,Mark A. Febbraio,Roger Gutierrez-Juarez,Irwin J. Kurland,Domenico Accili +10 more
TL;DR: It is proposed that FoxOs are required to enable the liver to direct nutritionally derived carbons to glucose vs. lipid metabolism, and the heterogeneity of hepatic insulin resistance during progression from the metabolic syndrome to overt diabetes is highlighted.
Journal ArticleDOI
Selective Inhibition of FOXO1 Activator/Repressor Balance Modulates Hepatic Glucose Handling.
Fanny Langlet,Rebecca A. Haeusler,Daniel Lindén,Elke Ericson,Tyrrell Norris,Anders Johansson,Joshua R. Cook,Kumiko S. Aizawa,Ling Wang,Christoph Buettner,Domenico Accili +10 more
TL;DR: It is reported that SIN3A is the insulin-sensitive FOXO1 corepressor of glucokinase, and the possibility of developing selective modulators of unliganded transcription factors to dial out adverse effects of insulin sensitizers is raised.
Journal ArticleDOI
Adipocyte SIRT1 knockout promotes PPARγ activity, adipogenesis and insulin sensitivity in chronic-HFD and obesity.
Rafael Mayoral,Olivia Osborn,Joanne C. McNelis,Andrew M.F. Johnson,Da Young Oh,Cristina Llorente Izquierdo,Heekyung Chung,Pingping Li,Paqui G. Través,Gautam Bandyopadhyay,Ariane Pessentheiner,Jachelle M. Ofrecio,Joshua R. Cook,Li Qiang,Domenico Accili,Jerrold M. Olefsky +15 more
TL;DR: It is established that SIRT1 downregulation in adipose tissue plays a previously unknown role in long-term inflammation resolution mediated by PPARγ activation and may provide novel approaches to the treatment of T2DM.