J
Judith Klein-Seetharaman
Researcher at Colorado School of Mines
Publications - 197
Citations - 11039
Judith Klein-Seetharaman is an academic researcher from Colorado School of Mines. The author has contributed to research in topics: Rhodopsin & G protein-coupled receptor. The author has an hindex of 52, co-authored 185 publications receiving 9334 citations. Previous affiliations of Judith Klein-Seetharaman include University of Warwick & University of Pittsburgh.
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Journal ArticleDOI
Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis
Valerian E. Kagan,Gaowei Mao,Feng Qu,José Pedro Friedmann Angeli,Sebastian Doll,Claudette M. St. Croix,Haider H. Dar,Bing Liu,Vladimir A. Tyurin,Vladimir B. Ritov,Alexandr A. Kapralov,Andrew A. Amoscato,Jianfei Jiang,Tamil S. Anthonymuthu,Dariush Mohammadyani,Qin Yang,Bettina Proneth,Judith Klein-Seetharaman,Simon C. Watkins,Ivet Bahar,Joel S. Greenberger,Rama K. Mallampalli,Brent R. Stockwell,Yulia Y. Tyurina,Marcus Conrad,Hülya Bayır +25 more
TL;DR: It is discovered that ferroptosis involves a highly organized oxygenation center, wherein oxidation in endoplasmic-reticulum-associated compartments occurs on only one class of phospholipids (phosphatidylethanolamines (PEs) and is specific toward two fatty acyls-arachidonoyl (AA) and AdA (AdA).
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Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells
Charleen T. Chu,Jing Ji,Ruben K. Dagda,Jianfei Jiang,Yulia Y. Tyurina,Alexandr A. Kapralov,Vladimir A. Tyurin,Naveena Yanamala,Indira H. Shrivastava,Dariush Mohammadyani,Kent Z.Q. Wang,Jianhui Zhu,Judith Klein-Seetharaman,Krishnakumar Balasubramanian,Andrew A. Amoscato,Grigory G. Borisenko,Zhentai Huang,Aaron M. Gusdon,Amin Cheikhi,Erin Steer,Ruth Wang,Catherine J. Baty,Simon C. Watkins,Ivet Bahar,Hülya Bayır,Valerian E. Kagan +25 more
TL;DR: Red redistribution of cardiolipin serves as an ‘eat-me’ signal for the elimination of damaged mitochondria from neuronal cells as well as the engulfment of mitochondria by the autophagic system.
Journal ArticleDOI
Carbon nanotubes degraded by neutrophil myeloperoxidase induce less pulmonary inflammation
Valerian E. Kagan,Nagarjun V. Konduru,Weihong Feng,Brett L. Allen,Jennifer Conroy,Yuri Volkov,Irina I. Vlasova,Natalia A. Belikova,Naveena Yanamala,Alexander A. Kapralov,Yulia Y. Tyurina,Jingwen Shi,Elena R. Kisin,Ashley R. Murray,Jonathan Franks,Donna B. Stolz,Pingping Gou,Judith Klein-Seetharaman,Bengt Fadeel,Alexander Star,Anna A. Shvedova +20 more
TL;DR: It is shown that hypochlorite and reactive radical intermediates of the human neutrophil enzyme myeloperoxidase catalyse the biodegradation of single-walled carbon nanotubes in vitro, in neutrophils and to a lesser degree in macrophages.
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Long-Range Interactions Within a Nonnative Protein
Judith Klein-Seetharaman,Maki Oikawa,Shaun B. Grimshaw,Julia Wirmer,Elke Duchardt,Tadashi Ueda,Taiji Imoto,Lorna J. Smith,Christopher M. Dobson,Harald Schwalbe +9 more
TL;DR: NMR spectroscopy and site-directed mutagenesis data show that nativelike structure in the denatured protein is stabilized by the involvement of Trp62 in nonnative and long-range interactions.
Journal ArticleDOI
Evaluation of different biological data and computational classification methods for use in protein interaction prediction
TL;DR: In this article, the authors investigated the utility of different data sources and the way the data is encoded as features for predicting each of these types of protein interactions, and assembled a large set of biological features and varied their encoding for use in each of the three prediction tasks.