T
Tamil S. Anthonymuthu
Researcher at University of Pittsburgh
Publications - 44
Citations - 3609
Tamil S. Anthonymuthu is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Cardiolipin & Medicine. The author has an hindex of 19, co-authored 36 publications receiving 1901 citations. Previous affiliations of Tamil S. Anthonymuthu include Brigham Young University & Boston Children's Hospital.
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Journal ArticleDOI
Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis
Valerian E. Kagan,Gaowei Mao,Feng Qu,José Pedro Friedmann Angeli,Sebastian Doll,Claudette M. St. Croix,Haider H. Dar,Bing Liu,Vladimir A. Tyurin,Vladimir B. Ritov,Alexandr A. Kapralov,Andrew A. Amoscato,Jianfei Jiang,Tamil S. Anthonymuthu,Dariush Mohammadyani,Qin Yang,Bettina Proneth,Judith Klein-Seetharaman,Simon C. Watkins,Ivet Bahar,Joel S. Greenberger,Rama K. Mallampalli,Brent R. Stockwell,Yulia Y. Tyurina,Marcus Conrad,Hülya Bayır +25 more
TL;DR: It is discovered that ferroptosis involves a highly organized oxygenation center, wherein oxidation in endoplasmic-reticulum-associated compartments occurs on only one class of phospholipids (phosphatidylethanolamines (PEs) and is specific toward two fatty acyls-arachidonoyl (AA) and AdA (AdA).
Journal ArticleDOI
PEBP1 Wardens Ferroptosis by Enabling Lipoxygenase Generation of Lipid Death Signals
Sally E. Wenzel,Yulia Y. Tyurina,Jinming Zhao,Claudette M. St. Croix,Haider H. Dar,Gaowei Mao,Vladimir A. Tyurin,Tamil S. Anthonymuthu,Alexandr A. Kapralov,Andrew A. Amoscato,Karolina Mikulska-Ruminska,Karolina Mikulska-Ruminska,Indira H. Shrivastava,Elizabeth M. Kenny,Qin Yang,Joel C. Rosenbaum,Louis J. Sparvero,David R. Emlet,Xiaoyan Wen,Yoshinori Minami,Feng Qu,Simon C. Watkins,Theodore R. Holman,Andrew P. VanDemark,John A. Kellum,Ivet Bahar,Hülya Bayır,Hülya Bayır,Valerian E. Kagan +28 more
TL;DR: It is discovered that PEBP1, a scaffold protein inhibitor of protein kinase cascades, complexes with two 15LO isoforms, 15LO1 and 15LO2, and changes their substrate competence to generate hydroperoxy-PE, a new target for drug discovery.
Journal ArticleDOI
Redox lipid reprogramming commands susceptibility of macrophages and microglia to ferroptotic death.
Alexandr A. Kapralov,Qin Yang,Haider H. Dar,Yulia Y. Tyurina,Tamil S. Anthonymuthu,Rina Kim,Rina Kim,Claudette M. St. Croix,Karolina Mikulska-Ruminska,Karolina Mikulska-Ruminska,Bing Liu,Indira H. Shrivastava,Vladimir A. Tyurin,Hsiu-Chi Ting,Yijen L. Wu,Yuan Gao,Galina V. Shurin,Margarita A Artyukhova,Liubov A. Ponomareva,Peter S. Timashev,Rosário Domingues,Detcho A. Stoyanovsky,Joel S. Greenberger,Rama K. Mallampalli,Ivet Bahar,Dmitry I. Gabrilovich,Hülya Bayır,Valerian E. Kagan +27 more
TL;DR: It is discovered that inducible nitric oxide synthase (iNOS)/NO • -enrichment of activated M1 (but not alternatively activated M2) macrophages/microglia modulates susceptibility to ferroptosis.
Journal ArticleDOI
Ferroptosis Contributes to Neuronal Death and Functional Outcome After Traumatic Brain Injury
Elizabeth M. Kenny,Emin Fidan,Qin Yang,Tamil S. Anthonymuthu,Lee Ann New,Elizabeth A. Meyer,Hong Wang,Patrick M. Kochanek,C. Edward Dixon,Valerian E. Kagan,Hülya Bayır +10 more
TL;DR: Baicalein decreased ferroptotic phosphatidylethanolamine oxidation and improved outcome after controlled cortical impact, suggesting that 15-lipoxygenase pathway might be a valuable therapeutic target after traumatic brain injury.
Journal ArticleDOI
A mitochondrial pathway for biosynthesis of lipid mediators.
Yulia Y. Tyurina,Samuel M. Poloyac,Vladimir A. Tyurin,Alexander A. Kapralov,Jianfei Jiang,Tamil S. Anthonymuthu,Valentina I. Kapralova,Anna S. Vikulina,Mi-Yeon Jung,Michael W. Epperly,Dariush Mohammadyani,Judith Klein-Seetharaman,Travis C. Jackson,Patrick M. Kochanek,Bruce R. Pitt,Joel S. Greenberger,Yury A. Vladimirov,Hülya Bayır,Valerian E. Kagan +18 more
TL;DR: This work reports that a range of diversified polyunsaturated molecular species derived from a mitochondria-specific phospholipid, cardiolipin, are oxidized by the intermembrane space hemoprotein, cytochrome c, thus generating multiple oxygenated fatty acids, including well known lipid mediators.