T
Tooraj Mirshahi
Researcher at Geisinger Health System
Publications - 83
Citations - 4871
Tooraj Mirshahi is an academic researcher from Geisinger Health System. The author has contributed to research in topics: Internal medicine & Medicine. The author has an hindex of 31, co-authored 69 publications receiving 3784 citations. Previous affiliations of Tooraj Mirshahi include Geisinger Medical Center & University of Texas Southwestern Medical Center.
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Journal ArticleDOI
A Protein-Truncating HSD17B13 Variant and Protection from Chronic Liver Disease
Noura S. Abul-Husn,Xiping Cheng,Alexander H. Li,Yurong Xin,Claudia Schurmann,Panayiotis Stevis,Yashu Liu,Julia Kozlitina,Stefan Stender,G. Craig Wood,Ann Stepanchick,Matthew D. Still,Shane McCarthy,Colm O'Dushlaine,Jonathan S. Packer,Suganthi Balasubramanian,Nehal Gosalia,David Esopi,Sun Y. Kim,Semanti Mukherjee,Alexander E. Lopez,Erin D. Fuller,John Penn,Xin Chu,Jonathan Z. Luo,Uyenlinh L. Mirshahi,David J. Carey,Christopher D. Still,Michael Feldman,Aeron Small,Scott M. Damrauer,Daniel J. Rader,Brian Zambrowicz,William C. Olson,Andrew J. Murphy,Ingrid B. Borecki,Alan R. Shuldiner,Jeffrey G. Reid,John D. Overton,George D. Yancopoulos,Helen H. Hobbs,Jonathan C. Cohen,Omri Gottesman,Tanya M. Teslovich,Aris Baras,Tooraj Mirshahi,Jesper Gromada,Frederick E. Dewey +47 more
TL;DR: A loss‐of‐function variant in HSD17B13 was associated with a reduced risk of chronic liver disease and of progression from steatosis to steatohepatitis.
Journal ArticleDOI
PIP2 Activates KCNQ Channels, and Its Hydrolysis Underlies Receptor-Mediated Inhibition of M Currents
Hailin Zhang,Liviu C Craciun,Tooraj Mirshahi,Tibor Rohacs,Coeli M. Lopes,Taihao Jin,Diomedes E. Logothetis +6 more
TL;DR: This work shows that a common feature of all KCNQ channels is their activation by the signaling membrane phospholipid phosphatidylinositol-bis-phosphate (PIP(2).
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Activation of inwardly rectifying K+ channels by distinct PtdIns(4,5)P2 interactions.
TL;DR: Two conserved residues near the inner-membrane interface of channels that are critical in interactions with PtdIns(4,5)P2 are identified and provided a mechanistic framework for understanding how distinct gating mechanisms of inwardly rectifying potassium channels allow these channels to subserve their physiological roles.
Journal ArticleDOI
Receptor-mediated hydrolysis of plasma membrane messenger PIP2 leads to K+-current desensitization.
TL;DR: It is shown in both native cardiac cells and heterologous expression systems that receptor-regulated PIP2 hydrolysis results in desensitization of a GTP-binding protein-stimulated potassium current, providing evidence that PIP1 itself is a receptor- regulated second messenger, downregulation of which accounts for a new form of desensItization.
Journal ArticleDOI
Characteristic interactions with phosphatidylinositol 4,5-bisphosphate determine regulation of Kir channels by diverse modulators
Xiaona Du,Hailin Zhang,Hailin Zhang,Coeli M. Lopes,Tooraj Mirshahi,Tibor Rohacs,Diomedes E. Logothetis +6 more
TL;DR: It is demonstrated that the strength of channel-PIP2 interactions determines the sensitivity of Kir channels to regulation by the various modulators and suggested that differences among Kir channels in their specific regulation by a given modulator may reflect differences in their apparent affinity.