George Hindy

TL;DR: In this paper, a Mendelian randomisation analysis was performed to compare the effect of HDL cholesterol, LDL cholesterol, and genetic score on risk of myocardial infarction.

TL;DR: Mendelian randomisation analyses challenge the concept that raising of plasma HDL cholesterol will uniformly translate into reductions in risk of myocardial infarction.

TL;DR: Rare mutations that disrupt AP OC3 function were associated with lower levels of plasma triglycerides and APOC3, and carriers of these mutations were found to have a reduced risk of coronary heart disease.

TL;DR: Evidence is provided for an association between the MBOAT7 rs641738 variant and the development and severity of NAFLD in individuals of European descent that seems to be mediated by changes in the hepatic phosphatidylinositol acyl-chain remodeling.

TL;DR: Although the "Exome Array" was used to genotype >200,000 low-frequency and rare coding sequence variants across the genome in 56,538 individuals, none of these four variants was associated with risk for CHD, suggesting that examples of low- frequencies with robust effects on both lipids and CHD will be limited.