J
Junchen Chen
Researcher at Boston Children's Hospital
Publications - 7
Citations - 410
Junchen Chen is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Neurogenesis & Neural stem cell. The author has an hindex of 5, co-authored 7 publications receiving 225 citations. Previous affiliations of Junchen Chen include Zhejiang University.
Papers
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Journal ArticleDOI
Fat Mass and Obesity-associated (FTO) Protein Regulates Adult Neurogenesis.
Liping Li,Liping Li,Liqun Zang,Liqun Zang,Feiran Zhang,Junchen Chen,Junchen Chen,Hui Shen,Hui Shen,Liqi Shu,Liqi Shu,Feng Liang,Feng Liang,Chunyue Feng,Deng Chen,Huikang Tao,Tianlei Xu,Ziyi Li,Yunhee Kang,Hao Wu,Lichun Tang,Pumin Zhang,Peng Jin,Qiang Shu,Xuekun Li,Xuekun Li +25 more
TL;DR: It is shown that FTO is expressed in adult neural stem cells and neurons and displays dynamic expression during postnatal neurodevelopment and this results suggest FTO plays important roles in neurogenesis, as well as in learning and memory.
Journal ArticleDOI
m6A Regulates Neurogenesis and Neuronal Development by Modulating Histone Methyltransferase Ezh2.
Junchen Chen,Yi-Chang Zhang,Chun-Min Huang,Hui Shen,Bao-Fa Sun,Xuejun Cheng,Yu-Jie Zhang,Yun-Gui Yang,Qiang Shu,Ying Yang,Xuekun Li,Xuekun Li +11 more
TL;DR: Results uncover a crosstalk between RNA and histone modifications and indicate that Mettl3-mediated m6A modification plays an important role in regulating neurogenesis and neuronal development through modulating Ezh2.
Journal ArticleDOI
Dynamic effects of Fto in regulating the proliferation and differentiation of adult neural stem cells of mice.
Yuhang Cao,Yuhang Cao,Yingliang Zhuang,Yingliang Zhuang,Junchen Chen,Junchen Chen,Weize Xu,Yikai Shou,Xiaoli Huang,Qiang Shu,Xuekun Li,Xuekun Li +11 more
TL;DR: An important function of Fto is revealed in regulating aNSCs through modulating Pdgfra/Socs5-Stat3 pathway and can rescue the neurogenic deficits induced by Fto depletion.
Journal ArticleDOI
Ogt controls neural stem/progenitor cell pool and adult neurogenesis through modulating Notch signaling
Junchen Chen,Xiaoxue Dong,Xiaoxue Dong,Xuejun Cheng,Qiang Zhu,Jinyu Zhang,Jinyu Zhang,Qian Li,Qian Li,Xiaoli Huang,Min Wang,Liping Li,Weixiang Guo,Binggui Sun,Qiang Shu,Wen Yi,Xuekun Li +16 more
TL;DR: In this paper, the role of Ogt in regulating neurogenesis and cognitive function in adult mice was investigated and it was shown that Ogt deficiency or depletion in adult neural stem/progenitor cells (aNSPCs) leads to the diminishment of the aNSPC pool and aberrant neurogenis and consequently impairs cognitive function.
Journal ArticleDOI
The Dynamic DNA Demethylation during Postnatal Neuronal Development and Neural Stem Cell Differentiation.
Huikang Tao,Pei Xie,Pei Xie,Yuhang Cao,Yuhang Cao,Liqi Shu,Liping Li,Liping Li,Junchen Chen,Junchen Chen,Guangfeng Tian,Guangfeng Tian,Yingliang Zhuang,Yingliang Zhuang,Qiang Shu,Xuekun Li,Xuekun Li +16 more
TL;DR: It was found that 5hmC, 5fC, and 5caC were highly enriched in multiple brain regions and aNSCs and displayed temporal and spatial patterns during postnatal neuronal development and the differentiation of aN SCs of mice.