Junichi Kikuta

TL;DR: A neuron-glia interaction that is indispensable for network formation during a specific period in the developing brain is highlighted, with microglia-derived IGF1 as a trophic factor that maintained neuronal survival.

TL;DR: Chemotaxis and chemorepulsion of osteoclast precursors depends on S1P concentrations and expression of the receptors S1 PR1 and S1PR2, which act to regulate osteocline precursor localization.

TL;DR: It is shown that mitochondrial membrane potential is diminished in RasV12-transformed cells when they are surrounded by normal cells, which indicates that non-cell-autonomous metabolic modulation is a crucial regulator for cell competition, shedding light on the unexplored events at the initial stage of carcinogenesis.

TL;DR: It is shown that Th17 cells, a subset of RankL-expressing CD4+ T cells, could induce rapid N-to-R conversion of mature osteoclasts via cell-cell contact, suggesting a novel point of action in RANKL-mediated control of mature bone resorptive function.

TL;DR: This is the first report demonstrating that normal epithelial cells recognize and actively eliminate neighbouring transformed cells and that filamin is a key mediator in the interaction between normal and transformed epithelium cells.