Hiroto Katoh

TL;DR: The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies.

TL;DR: The presence of high levels of both CD8+ T cells and CD4- T cells is a significant indicator of a better prognosis for patients with NSCLC, and cooperation between these cell populations may allow a significantly more potent antitumour response than either population alone.

TL;DR: Somatic inactivating mutations and deletion of the X-linked FOXP3 gene residing at Xp11.23 in human prostate cancer are reported to represent a paradigm of "single genetic hit" inactivation-mediated carcinogenesis.

TL;DR: It is shown that mitochondrial membrane potential is diminished in RasV12-transformed cells when they are surrounded by normal cells, which indicates that non-cell-autonomous metabolic modulation is a crucial regulator for cell competition, shedding light on the unexplored events at the initial stage of carcinogenesis.

TL;DR: The subchromosomal numerical aberrations of 44 surgically resected pancreatic adenocarcinomas were analyzed by array‐based comparative genomic hybridization, suggesting the presence of multiple or complementary mechanisms of evolution in pancreatic cancer.