J
Jürgen Sühnel
Researcher at National Institutes of Health
Publications - 76
Citations - 3258
Jürgen Sühnel is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Hydrogen bond & Protein Data Bank. The author has an hindex of 30, co-authored 76 publications receiving 3084 citations. Previous affiliations of Jürgen Sühnel include Institute of Molecular Biotechnology & University of Jena.
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Journal ArticleDOI
C-h⋯π-interactions in proteins
TL;DR: A non-redundant set of 1154 protein structures from the Protein Data Bank was examined with respect to close interactions between C-H-donor and pi-acceptor groups as mentioned in this paper.
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More hydrogen bonds for the (structural) biologist.
TL;DR: This work postulates that the incorporation of the entirety of these interactions leads to a more complete description of the problem, and that this could provide new perspectives and possibly new answers to protein structure and stability questions.
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Defective complement control of Factor H (Y402H) and FHL-1 in age-related macular degeneration
Christine Skerka,Nadine Lauer,Andreas W. A. Weinberger,Claudia N. Keilhauer,Jürgen Sühnel,Richard J.H. Smith,Ursula Schlötzer-Schrehardt,Lars G. Fritsche,Stefan Heinen,Andrea Hartmann,Bernhard H. F. Weber,Peter F. Zipfel,Peter F. Zipfel +12 more
TL;DR: It is shown that the risk variant CFH 402His displays reduced binding to C reactive protein (CRP), heparin and retinal pigment epithelial cells, which can cause inefficient complement regulation at the cell surface, and may lead to AMD pathogenesis.
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Toxicology of simple and complex mixtures
TL;DR: In this article, options for the hazard identification and risk assessment of simple and complex chemical mixtures will be discussed and key research needed to continue the development of hazard characterization of chemical mixture will be described.
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Branched-chain amino acid catabolism is a conserved regulator of physiological ageing
Johannes Mansfeld,Nadine Urban,Steffen Priebe,Marco Groth,Christiane Frahm,Nils Hartmann,Juliane Gebauer,Meenakshi Ravichandran,Anne Dommaschk,Sebastian Schmeisser,Doreen Kuhlow,Shamci Monajembashi,Sibylle Bremer-Streck,Peter Hemmerich,Michael Kiehntopf,Nicola Zamboni,Christoph Englert,Christoph Englert,Reinhard Guthke,Christoph Kaleta,Matthias Platzer,Jürgen Sühnel,Otto W. Witte,Kim Zarse,Kim Zarse,Michael Ristow +25 more
TL;DR: BCAAs act as periphery-derived metabokines that induce a central neuro-endocrine response, culminating in extended healthspan in nematodes, zebrafish and mice.