J
Justine Decroocq
Researcher at University of Paris
Publications - 22
Citations - 580
Justine Decroocq is an academic researcher from University of Paris. The author has contributed to research in topics: Medicine & Myeloid leukemia. The author has an hindex of 6, co-authored 9 publications receiving 339 citations. Previous affiliations of Justine Decroocq include Centre national de la recherche scientifique & French Institute of Health and Medical Research.
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Journal ArticleDOI
Targeting glutaminolysis has antileukemic activity in acute myeloid leukemia and synergizes with BCL-2 inhibition.
Nathalie Jacque,Anne Marie Ronchetti,Clément Larrue,Clément Larrue,Godelieve Meunier,Rudy Birsen,Lise Willems,Estelle Saland,Estelle Saland,Justine Decroocq,Thiago Trovati Maciel,Mireille Lambert,Laury Poulain,Pierre Sujobert,Laure Joseph,Nicolas Chapuis,Nicolas Chapuis,Catherine Lacombe,Catherine Lacombe,Ivan C. Moura,Susan Demo,Jean-Emmanuel Sarry,Jean-Emmanuel Sarry,Christian Recher,Christian Recher,Patrick Mayeux,Patrick Mayeux,Jerome Tamburini,Didier Bouscary +28 more
TL;DR: It is shown that glutamine levels control mitochondrial oxidative phosphorylation (OXPHOS) in acute myeloid leukemia (AML) cells and targeting glutamine addiction via GLS1 inhibition offers a potential novel therapeutic strategy for AML.
Journal ArticleDOI
Pim kinases modulate resistance to FLT3 tyrosine kinase inhibitors in FLT3-ITD acute myeloid leukemia
Alexa S. Green,Thiago Trovati Maciel,Chae Yin,Fetta Mazed,Fetta Mazed,Elizabeth C. Townsend,Sylvain Pilorge,Mireille Lambert,Mireille Lambert,Etienne Paubelle,Arnaud Jacquel,Florence Zylbersztejn,Justine Decroocq,Laury Poulain,Laury Poulain,Pierre Sujobert,Pierre Sujobert,Nathalie Jacque,Nathalie Jacque,Kevin Adam,Kevin Adam,Jason C. C. So,Olivier Kosmider,Olivier Kosmider,Patrick Auberger,Olivier Hermine,David M. Weinstock,Catherine Lacombe,Catherine Lacombe,Patrick Mayeux,Patrick Mayeux,Gary J. Vanasse,Anskar Y.H. Leung,Ivan C. Moura,Didier Bouscary,Didier Bouscary,Jerome Tamburini,Jerome Tamburini +37 more
TL;DR: It is found that Pim kinases governFLT3-ITD signaling and that their pharmacological or genetic inhibition restores cell sensitivity to FLT3 inhibitors, which represents a promising new avenue for AML therapy.
Journal ArticleDOI
APR-246 induces early cell death by ferroptosis in acute myeloid leukemia.
Rudy Birsen,Clement Larrue,Justine Decroocq,Natacha Johnson,Nathan Guiraud,Mathilde Gotanègre,Lilia Cantero-Aguilar,Eric Grignano,Tony Huynh,Michaela Fontenay,Olivier Kosmider,Patrick Mayeux,Nicolas Chapuis,Jean-Emmanuel Sarry,Jerome Tamburini,Didier Bouscary +15 more
TL;DR: In this paper, the authors demonstrate that AML cell death occurring early after APR-246 exposure is suppressed by iron chelators, lipophilic antioxidants and inhibitors of lipid peroxidation.
Journal ArticleDOI
Vitamin D Receptor Controls Cell Stemness in Acute Myeloid Leukemia and in Normal Bone Marrow
Etienne Paubelle,Florence Zylbersztejn,Florence Zylbersztejn,Florence Zylbersztejn,Thiago Trovati Maciel,Caroline Carvalho,Annalisa Mupo,Meyling Cheok,Liesbet Lieben,Pierre Sujobert,Pierre Sujobert,Justine Decroocq,Justine Decroocq,Justine Decroocq,Akihiko Yokoyama,Vahid Asnafi,Elizabeth Macintyre,Jerome Tamburini,Jerome Tamburini,Valérie Bardet,Valérie Bardet,Valérie Bardet,Sylvie Castaigne,Claude Preudhomme,Hervé Dombret,Geert Carmeliet,Didier Bouscary,Didier Bouscary,Yelena Ginzburg,Marc Benhamou,Renato C. Monteiro,George S. Vassiliou,Olivier Hermine,Ivan C. Moura +33 more
TL;DR: An unexpected role of VDR in normal hematopoiesis and in leukemogenesis is presented and it is shown that Vdr functions as a regulator of stem cell homeostasis and leukemic propagation.
Journal ArticleDOI
RSK2 is a new Pim2 target with pro-survival functions in FLT3-ITD-positive acute myeloid leukemia
Arnaud Jacquel,Fetta Mazed,Fetta Mazed,Estelle Saland,Estelle Saland,Clément Larrue,Clément Larrue,Johanna Mondesir,Johanna Mondesir,Rudy Birsen,Rudy Birsen,Alexa S. Green,Alexa S. Green,Mireille Lambert,Mireille Lambert,Pierre Sujobert,Pierre Sujobert,E.F. Gautier,V Salnot,M. Le Gall,M. Le Gall,Justine Decroocq,Justine Decroocq,Laury Poulain,Laury Poulain,Nathalie Jacque,Nathalie Jacque,Michaela Fontenay,Michaela Fontenay,Olivier Kosmider,Olivier Kosmider,Christian Récher,Christian Récher,Patrick Auberger,Patrick Mayeux,Patrick Mayeux,Didier Bouscary,Didier Bouscary,J-E Sarry,J-E Sarry,Jerome Tamburini,Jerome Tamburini +41 more
TL;DR: The results point to RSK2 as a novel Pim2 target with translational therapeutic potential in FLT3-ITD AML, and show that RPS6KA3 knockdown reduced the propagation of human AML cells in vivo in mice.