Organ printing can be defined as layer-by-layer additive robotic biofabrication of three-dimensional functional living macrotissues and organ constructs using tissue spheroids as building blocks. The microtissues and tissue spheroids are living materials with certain measurable, evolving and potentially controllable composition, material and biological properties. Closely placed tissue spheroids undergo tissue fusion - a process that represents a fundamental biological and biophysical principle of developmental biology-inspired directed tissue self-assembly. It is possible to engineer small segments of an intraorgan branched vascular tree by using solid and lumenized vascular tissue spheroids. Organ printing could dramatically enhance and transform the field of tissue engineering by enabling large-scale industrial robotic biofabrication of living human organ constructs with "built-in" perfusable intraorgan branched vascular tree. Thus, organ printing is a new emerging enabling technology paradigm which represents a developmental biology-inspired alternative to classic biodegradable solid scaffold-based approaches in tissue engineering.

Organ Printing: Tissue Spheroids as Building Blocks

Synthetic potential of the tertiary-amine-catalysed reaction of activated vinyl carbanions with aldehydes

This work was supported by the Foundation for Science and Technology (FCT), Portugal (projects PTDC/QUI-QUI/113687/2009 and PEst-C/QUI/UI0081/2013). A.G. (SFRH/BD/43531/2008) and M.J.M. (SFRH/BD/61262/2009) thank FCT for grants.

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Chromone: A Valid Scaffold in Medicinal Chemistry

o-Quinone methides: intermediates underdeveloped and underutilized in organic synthesis

https://www.ircc.iitb.ac.in/IRCC-Webpage/rnd/PDF/Awards11KothaS.pdf

Transition Metal Catalyzed (2+2+2) Cycloaddition and Application in Organic Synthesis

Electrohydrodimerization of 4-chloro-3-formyl-2H(1)-benzopyrans in ethanolic solutions: A comparative study

A one pot synthesis of a number of 4-chlorochromenes and chroman-4-ones was achieved from γ-chloropropargyl aryl ethers proceeding through Claisen rearrangement, depending upon the solvent of choice.

A Simple Route for the Synthesis of 4-Chlorochromenes and Chroman-4-ones.

Synthesis of 4‐amino‐4,6‐dideoxy‐d‐allose derivatives

Halogen-Exchange Fluorination of β-Chlorovinyl Aldehydes – Unexpected Cascade Transformations in the Fluorination of 4-Chloro-2H-chromene and 4-Chloro-2H-thiochromene-3-carbaldehydes

Chromone-3-ylmethyl aryl ethers (I) undergo a novel domino [1,3]-[1,3]-rearrangement to give 4′-hydroxyhomoisoflavones (II) under thermal conditions whereas, the para-substituted ethers (IV) lead to 2′-hydroxyhomoisoflavones instead of the expected Claisen rearrangement.

An Unexpected Thermal [1,3]-[1,3]-para Rearrangement of Chromone-3-ylmethyl Aryl Ethers: Mechanism and Application of the Intercepted [1,3]-Rearranged Intermediates to the Synthesis of cis-Homopterocarpans.

Kalpattu K. Balasubramanian

Papers

Electrohydrodimerization of 4-chloro-3-formyl-2H(1)-benzopyrans in ethanolic solutions: A comparative study

A Simple Route for the Synthesis of 4-Chlorochromenes and Chroman-4-ones.

Synthesis of 4‐amino‐4,6‐dideoxy‐d‐allose derivatives

Halogen-Exchange Fluorination of β-Chlorovinyl Aldehydes – Unexpected Cascade Transformations in the Fluorination of 4-Chloro-2H-chromene and 4-Chloro-2H-thiochromene-3-carbaldehydes

An Unexpected Thermal [1,3]-[1,3]-para Rearrangement of Chromone-3-ylmethyl Aryl Ethers: Mechanism and Application of the Intercepted [1,3]-Rearranged Intermediates to the Synthesis of cis-Homopterocarpans.