Organ printing can be defined as layer-by-layer additive robotic biofabrication of three-dimensional functional living macrotissues and organ constructs using tissue spheroids as building blocks. The microtissues and tissue spheroids are living materials with certain measurable, evolving and potentially controllable composition, material and biological properties. Closely placed tissue spheroids undergo tissue fusion - a process that represents a fundamental biological and biophysical principle of developmental biology-inspired directed tissue self-assembly. It is possible to engineer small segments of an intraorgan branched vascular tree by using solid and lumenized vascular tissue spheroids. Organ printing could dramatically enhance and transform the field of tissue engineering by enabling large-scale industrial robotic biofabrication of living human organ constructs with "built-in" perfusable intraorgan branched vascular tree. Thus, organ printing is a new emerging enabling technology paradigm which represents a developmental biology-inspired alternative to classic biodegradable solid scaffold-based approaches in tissue engineering.

Organ Printing: Tissue Spheroids as Building Blocks

Synthetic potential of the tertiary-amine-catalysed reaction of activated vinyl carbanions with aldehydes

This work was supported by the Foundation for Science and Technology (FCT), Portugal (projects PTDC/QUI-QUI/113687/2009 and PEst-C/QUI/UI0081/2013). A.G. (SFRH/BD/43531/2008) and M.J.M. (SFRH/BD/61262/2009) thank FCT for grants.

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Chromone: A Valid Scaffold in Medicinal Chemistry

o-Quinone methides: intermediates underdeveloped and underutilized in organic synthesis

https://www.ircc.iitb.ac.in/IRCC-Webpage/rnd/PDF/Awards11KothaS.pdf

Transition Metal Catalyzed (2+2+2) Cycloaddition and Application in Organic Synthesis

Synthesis of spirobenzofurans based on photochemical ‘δ’ hydrogen abstraction is reported.

A Photochemical Entry to Spirobenzofurans.

Treatment of tri-O acetyl-D-glucal 1 with diverse thiols 2–7 in the presence of LiBF4 in CH3CN, furnished aryl/alkyl 2,3-unsaturated thioglycopyranosides 8–13 (56–72%).

Synthesis of 2,3‐Unsaturated Thioglycopyranosides Mediated by Lithium Tetrafluoroborate.

3-Hydroxymethylchromones have been found to undergo a novel transformation in the presence of Cs2CO3 in toluene or xylene as solvent to afford “trimeric” chromones, 3,3-bis-(4-chromone-3-ylmethyl)-chroman-4-ones. The structure of the trimer has also been confirmed by single-crystal x-ray diffraction study. Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications® to view the free supplemental file.

Novel Synthesis of 3,3‐Bis‐(4‐chromone‐3‐ylmethyl)‐chroman‐4‐ones

Regioselective Reductive Elimination of Aryloxymethylethynylcarbinols.

A simple and high yielding route to 3-alkylchromanones and 3-alkylchromones has been achieved from 3-alkyl-3-phenyl-sulphonyl-4-chromanones. A simple and high yielding route to 3-alkylchromanones and 3-alkylchromones has been achieved from 3-alkyl, 3-phenylsulphonyl-4-chromanones.

Kalpattu K. Balasubramanian

Papers

A Photochemical Entry to Spirobenzofurans.

Synthesis of 2,3‐Unsaturated Thioglycopyranosides Mediated by Lithium Tetrafluoroborate.

Novel Synthesis of 3,3‐Bis‐(4‐chromone‐3‐ylmethyl)‐chroman‐4‐ones

Regioselective Reductive Elimination of Aryloxymethylethynylcarbinols.

A Facile Synthesis of 3‐Alkylchromanones and Chromones.