K
Kanji Higashio
Researcher at St. Vincent's Institute of Medical Research
Publications - 64
Citations - 14658
Kanji Higashio is an academic researcher from St. Vincent's Institute of Medical Research. The author has contributed to research in topics: Osteoprotegerin & Osteoclast. The author has an hindex of 36, co-authored 64 publications receiving 14220 citations.
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Journal ArticleDOI
Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL
Hisataka Yasuda,Nobuyuki Shima,Nobuaki Nakagawa,Kyoji Yamaguchi,Masahiko Kinosaki,Shin Ichi Mochizuki,Akihiro Tomoyasu,Kazuki Yano,Masaaki Goto,Akihiko Murakami,Eisuke Tsuda,Tomonori Morinaga,Kanji Higashio,Nobuyuki Udagawa,Naoyuki Takahashi,Tatsuo Suda +15 more
TL;DR: In this article, a membrane-bound osteoclast differentiation factor (ODF) was found to induce OCL formation from osteoblasts/stromal cells in the presence of bone-resorbing factors.
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Identity of osteoclastogenesis inhibitory factor (OCIF) and osteoprotegerin (OPG): a mechanism by which OPG/OCIF inhibits osteoclastogenesis in vitro.
Hisataka Yasuda,Nobuyuki Shima,Nobuaki Nakagawa,Shinichi Mochizuki,Kazuki Yano,Nobuaki Fujise,Yasushi Sato,Masaaki Goto,Kyoji Yamaguchi,Masayoshi Kuriyama,Takeshi Kanno,Akihiko Murakami,Eisuke Tsuda,Tomonori Morinaga,Kanji Higashio +14 more
TL;DR: The cloning of a complementary DNA of human OCIF is reported, suggesting that the sites are involved in cell-to-cell signaling between stromal cells and osteoclast progenitors and that OPG/OCIF inhibits osteOClastogenesis by interrupting the signaling through the sites.
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Tumor Necrosis Factor α Stimulates Osteoclast Differentiation by a Mechanism Independent of the Odf/Rankl–Rank Interaction
Kanichiro Kobayashi,Naoyuki Takahashi,Eijiro Jimi,Nobuyuki Udagawa,Masamichi Takami,Shigeru Kotake,Nobuaki Nakagawa,Masahiko Kinosaki,Kyoji Yamaguchi,Nobuyuki Shima,Hisataka Yasuda,Tomonori Morinaga,Kanji Higashio,T. John Martin,Tatsuo Suda +14 more
TL;DR: It is demonstrated that TNF-α stimulates osteoclast differentiation in the presence of M-CSF through a mechanism independent of the ODF/RANKL–RANK system.
Journal ArticleDOI
Isolation of a novel cytokine from human fibroblasts that specifically inhibits osteoclastogenesis
Eisuke Tsuda,Masaaki Goto,Shinichi Mochizuki,Kazuki Yano,Fumie Kobayashi,Tomonori Morinaga,Kanji Higashio +6 more
TL;DR: Data suggest that OCIF is a novel cytokine which specifically inhibits osteoclastogenesis, and has no homology to known proteins.
Journal ArticleDOI
Severe osteoporosis in mice lacking osteoclastogenesis inhibitory factor/osteoprotegerin.
Atsuko Mizuno,Norio Amizuka,Kazuharu Irie,Akihiko Murakami,Nobuaki Fujise,Takeshi Kanno,Yasushi Sato,Nobuaki Nakagawa,Hisataka Yasuda,Shinichi Mochizuki,Takashi Gomibuchi,Kazuki Yano,Nobuyuki Shima,Naohiro Washida,Eisuke Tsuda,Tomonori Morinaga,Kanji Higashio,Hidehiro Ozawa +17 more
TL;DR: It is demonstrated that the OCIF/OPG knockout mice provide the first animal model for osteoporosis without other obvious abnormalities and is a key factor acting as a negative regulator against osteoclastogenesis.