K
Karen Wigg
Researcher at University Health Network
Publications - 72
Citations - 3017
Karen Wigg is an academic researcher from University Health Network. The author has contributed to research in topics: Attention deficit hyperactivity disorder & Transmission disequilibrium test. The author has an hindex of 31, co-authored 68 publications receiving 2874 citations. Previous affiliations of Karen Wigg include University of Toronto & Toronto Western Hospital.
Papers
More filters
Journal ArticleDOI
Identification of DNA variants in the SNAP-25 gene and linkage study of these polymorphisms and attention-deficit hyperactivity disorder.
Cathy L. Barr,Yu Feng,Karen Wigg,Stacey Bloom,Wendy Roberts,Molly Malone,Russell Schachar,Rosemary Tannock,James L. Kennedy +8 more
TL;DR: Four DNA sequence variants in the 3′ untranslated region of the human SNAP-25 gene are identified and a role of this gene in ADHD is suggestive.
Journal ArticleDOI
Joint analysis of the DRD5 marker concludes association with attention-deficit/hyperactivity disorder confined to the predominantly inattentive and combined subtypes.
N. Lowe,Aiveen Kirley,Ziarih Hawi,Pak C. Sham,Harvey Wickham,Christopher J. Kratochvil,Shelley D. Smith,Saretta Y. Lee,Florence Levy,Lindsey Kent,F. Middle,Luis Augusto Rohde,Tatiana Roman,Eda Tahir,Yanke Yazgan,Philip Asherson,Jonathan Mill,Anita Thapar,Antony Payton,Richard D. Todd,Timothy Stephens,Richard P. Ebstein,Iris Manor,Cathy L. Barr,Karen Wigg,Richard J. Sinke,Jan K. Buitelaar,Susan L. Smalley,Stan F. Nelson,Joseph Biederman,Stephen V. Faraone,Michael Gill +31 more
TL;DR: Genotypic information from 14 independent samples of probands and their parents and joint analysis showed association with the DRD5 locus, and this association appears to be confined to the predominantly inattentive and combined clinical subtypes.
Journal ArticleDOI
Haplotype study of three polymorphisms at the dopamine transporter locus confirm linkage to attention-deficit/hyperactivity disorder
Cathy L. Barr,Chun Xu,Jamie Kroft,Yu Feng,Karen Wigg,Gwyneth Zai,Rosemary Tannock,Russell Schachar,Molly Malone,Wendy Roberts,Markus M. Nöthen,Frank Grünhage,David J. Vandenbergh,George R. Uhl,Glen A. Sunohara,Nicole King,James L. Kennedy +16 more
TL;DR: The results support previous findings of an association between the DAT1 gene and ADHD and investigate the possibility of linkage of Dat1 and ADHD using the VNTR polymorphism and two additional common polymorphisms in 102 nuclear families with an ADHD proband.
Journal ArticleDOI
Support for EKN1 as the susceptibility locus for dyslexia on 15q21.
Karen Wigg,Jillian M. Couto,Yu Feng,Barbara Anderson,Tasha Cate-Carter,Fabio Macciardi,Rosemary Tannock,Maureen W. Lovett,Tom Humphries,Cathy L. Barr +9 more
TL;DR: Significant evidence for an association to dyslexia is found and evidence of association to the reading and related processes of phonological awareness, word identification, decoding, rapid automatized naming, language ability, and verbal short-term memory is found.
Journal ArticleDOI
Association of the glutamate receptor subunit gene GRIN2B with attention-deficit/hyperactivity disorder
Kimberley M. Dorval,Karen Wigg,Jennifer Crosbie,Rosemary Tannock,James L. Kennedy,Abel Ickowicz,Tejaswee Pathare,Molly Malone,Russell Schachar,Cathy L. Barr +9 more
TL;DR: The data suggest an association between variations in the GRIN2B subunit gene and ADHD as measured categorically or as a quantitatively distributed trait.