N
N. Lowe
Researcher at Trinity College, Dublin
Publications - 22
Citations - 2053
N. Lowe is an academic researcher from Trinity College, Dublin. The author has contributed to research in topics: Attention deficit hyperactivity disorder & Single-nucleotide polymorphism. The author has an hindex of 14, co-authored 21 publications receiving 1999 citations.
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The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: association signals in DRD4, DAT1 and 16 other genes.
Keeley J. Brookes,Xiaohui Xu,Wei J. Chen,Kaixin Zhou,Benjamin M. Neale,N. Lowe,R. Aneey,Barbara Franke,Michael Gill,Richard P. Ebstein,Jan K. Buitelaar,Pak C. Sham,Desmond Campbell,Joanne Knight,Penny Andreou,Marieke E. Altink,Raoul Arnold,Frits Boer,Cathelijne J. M. Buschgens,Louise Butler,Hanna Christiansen,Leonard C. Feldman,K. Fleischman,Ellen A. Fliers,Raoul Howe-Forbes,A. Goldfarb,Alexander Heise,Isabel Gabriëls,Isabelle Korn-Lubetzki,Rafaela Marco,She'era Medad,Rudolf Minderaa,Fernando Mulas,Ueli C Müller,Aisling Mulligan,K. Rabin,Nanda Rommelse,Vaheshta Sethna,J. Sorohan,Henrik Uebel,Lamprini Psychogiou,Anne Weeks,R. Barrett,Ian W. Craig,Tobias Banaschewski,Edmund J.S. Sonuga-Barke,J. Eisenberg,Jonna Kuntsi,Iris Manor,Peter McGuffin,Ana Miranda,Robert D. Oades,Robert Plomin,Herbert Roeyers,Aribert Rothenberger,Joseph A. Sergeant,Hans-Christoph Steinhausen,Eric Taylor,Margaret Thompson,Stephen V. Faraone,Philip Asherson,Lena Johansson +61 more
TL;DR: In this article, the authors examined 1038 single-nucleotide polymorphisms (SNPs) spanning 51 candidate genes involved in the regulation of neurotransmitter pathways, particularly dopamine, norepinephrine and serotonin pathways, in addition to circadian rhythm genes.
Journal ArticleDOI
Joint analysis of the DRD5 marker concludes association with attention-deficit/hyperactivity disorder confined to the predominantly inattentive and combined subtypes.
N. Lowe,Aiveen Kirley,Ziarih Hawi,Pak C. Sham,Harvey Wickham,Christopher J. Kratochvil,Shelley D. Smith,Saretta Y. Lee,Florence Levy,Lindsey Kent,F. Middle,Luis Augusto Rohde,Tatiana Roman,Eda Tahir,Yanke Yazgan,Philip Asherson,Jonathan Mill,Anita Thapar,Antony Payton,Richard D. Todd,Timothy Stephens,Richard P. Ebstein,Iris Manor,Cathy L. Barr,Karen Wigg,Richard J. Sinke,Jan K. Buitelaar,Susan L. Smalley,Stan F. Nelson,Joseph Biederman,Stephen V. Faraone,Michael Gill +31 more
TL;DR: Genotypic information from 14 independent samples of probands and their parents and joint analysis showed association with the DRD5 locus, and this association appears to be confined to the predominantly inattentive and combined clinical subtypes.
Journal ArticleDOI
Evidence that variation at the serotonin transporter gene influences susceptibility to attention deficit hyperactivity disorder (ADHD): analysis and pooled analysis.
Lindsey Kent,U. Doerry,E. Hardy,R. Parmar,K. Gingell,Ziarih Hawi,Aiveen Kirley,N. Lowe,Michael Fitzgerald,Michael Gill,Nicholas John Craddock +10 more
TL;DR: This study provides further evidence for the possible involvement of the serotonin transporter in susceptibility to ADHD.
Journal ArticleDOI
Association of the 480 bp DAT1 allele with methylphenidate response in a sample of Irish children with ADHD.
Aiveen Kirley,N. Lowe,Ziarih Hawi,Celine Mullins,Grainne Daly,Irwin D. Waldman,Mary McCarron,Deirdre O'Donnell,Michael Fitzgerald,Michael Gill +9 more
TL;DR: A role for the 10‐repeat VNTR DAT1 risk allele in medication response is suggested and may help to predict positive clinical outcome in ADHD.
Journal ArticleDOI
Linkage disequilibrium mapping at DAT1, DRD5 and DBH narrows the search for ADHD susceptibility alleles at these loci
Ziarih Hawi,N. Lowe,Aiveen Kirley,F. Gruenhage,Markus M. Nöthen,Tiffany A. Greenwood,John R. Kelsoe,Michael Fitzgerald,Michael Gill +8 more
TL;DR: This work confirmed the DAT1 association and also identified two additional susceptibility loci at the DRD5 and DBH, and analysed additional markers creating a high-density map across and flanking these genes, and measure intermarker linkage disequilibrium (LD).