Wendy Greenwood

TL;DR: The results show that measurement of genomically defined clonal population dynamics will be highly informative for functional studies using patient-derived breast cancer xenoengraftment, and indicates that genomic aberrations can be reproducible determinants of evolutionary trajectories.

TL;DR: A large collection of breast cancer patient-derived tumor xenografts (PDTXs) are created, in which the morphological and molecular characteristics of the originating tumor are preserved through passaging in the mouse, and the intra-tumor genomic clonal architecture present in the originating breast cancers was mostly preserved.

TL;DR: DLP+, a scalable single-cell whole-genome sequencing platform implemented using commodity instruments, image-based object recognition, and open source computational methods, has been developed and joint analysis over the above features defined clone-specific chromosomal aneuploidy in polyclonal populations.

TL;DR: Overexpression of ZNF703 in normal human breast epithelial cells enhanced the frequency of in vitro colony‐forming cells from luminal progenitors and strongly point to Z NF703 as a novel oncogene in Luminal B breast cancer.

TL;DR: It is shown that TGFβ increases breast tumour-initiating cell numbers but only in claudin(low) breast cancer cell lines by orchestrating a specific gene signature enriched in stem cell processes that predicts worse clinical outcome in breast cancer patients.