Hui Xue

TL;DR: The results show that measurement of genomically defined clonal population dynamics will be highly informative for functional studies using patient-derived breast cancer xenoengraftment, and indicates that genomic aberrations can be reproducible determinants of evolutionary trajectories.

TL;DR: A bank of transplantable patient-derived prostate cancer xenografts are established that capture the biologic and molecular heterogeneity currently confounding prognostication and therapy development and predict that these next-generation models will be transformative for advancing mechanistic understanding of disease progression, response to therapy, and personalized oncology.

TL;DR: The majority of advanced, treatment-resistant tumors across tumor types harbor biologically informative alterations, and the establishment of a clinical trial for WES of metastatic tumors with prospective follow-up of patients can help identify candidate predictive biomarkers of response.

TL;DR: RNA sequencing on paired metastatic/non-metastatic PCa xenografts derived from clinical specimens identified a PCAT18-associated expression signature (PES), which is highly PCa-specific and activated in metastatic vs. primary PCa samples (p<1E−4, odds ratio>2).

TL;DR: This work modeled the development of NEPC from conventional prostatic adenocarcinoma using a patient-derived xenograft and found that the placental gene PEG10 is de-repressed during the adaptive response to AR interference and subsequently highly upregulated in clinical NEPC.