K
Karin G. Hermans
Researcher at Princess Margaret Cancer Centre
Publications - 14
Citations - 1151
Karin G. Hermans is an academic researcher from Princess Margaret Cancer Centre. The author has contributed to research in topics: Stem cell & Haematopoiesis. The author has an hindex of 9, co-authored 12 publications receiving 993 citations. Previous affiliations of Karin G. Hermans include Hospital for Sick Children & University Health Network.
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Journal ArticleDOI
The unfolded protein response governs integrity of the haematopoietic stem-cell pool during stress
Peter van Galen,Antonija Kreso,Nathan Mbong,David G. Kent,Tim J. Fitzmaurice,Joseph E. Chambers,Stephanie Z. Xie,Elisa Laurenti,Karin G. Hermans,Kolja Eppert,Stefan J. Marciniak,Jane C. Goodall,Anthony R. Green,Bradly G. Wouters,Erno Wienholds,John E. Dick +15 more
TL;DR: It is shown that human HSCs are predisposed to apoptosis through strong activation of the PERK branch of the UPR after ER stress, whereas closely related progenitors exhibit an adaptive response leading to their survival.
Journal ArticleDOI
A Distinctive DNA Damage Response in Human Hematopoietic Stem Cells Reveals an Apoptosis-Independent Role for p53 in Self-Renewal
Michael Milyavsky,Michael Milyavsky,Olga I. Gan,Olga I. Gan,Magan Trottier,Martin Komosa,Ofer Tabach,Faiyaz Notta,Faiyaz Notta,Eric R. Lechman,Eric R. Lechman,Karin G. Hermans,Karin G. Hermans,Kolja Eppert,Kolja Eppert,Zhanna Konovalova,Zhanna Konovalova,Olga Ornatsky,Eytan Domany,M. Stephen Meyn,John E. Dick,John E. Dick +21 more
TL;DR: The data reveal distinct physiological roles of p53 that together ensure optimal HSC function: apoptosis regulation and prevention of gammaH2AX foci accumulation upon HSC self-renewal.
Journal ArticleDOI
miR-126 Regulates Distinct Self-Renewal Outcomes in Normal and Malignant Hematopoietic Stem Cells
Eric R. Lechman,Eric R. Lechman,Bernhard Gentner,Stanley W.K. Ng,Erwin M. Schoof,Erwin M. Schoof,Peter van Galen,Peter van Galen,James A. Kennedy,James A. Kennedy,Silvia Nucera,Fabio Ciceri,Kerstin B. Kaufmann,Kerstin B. Kaufmann,Naoya Takayama,Naoya Takayama,Stephanie M. Dobson,Stephanie M. Dobson,Aaron Trotman-Grant,Aaron Trotman-Grant,Gabriela Krivdova,Gabriela Krivdova,Janneke Elzinga,Janneke Elzinga,Amanda Mitchell,Amanda Mitchell,Björn Nilsson,Karin G. Hermans,Karin G. Hermans,Kolja Eppert,Rene Marke,Ruth Isserlin,Veronique Voisin,Gary D. Bader,Peter W. Zandstra,Todd R. Golub,Benjamin L. Ebert,Jun Lu,Mark D. Minden,Mark D. Minden,Jean C.Y. Wang,Jean C.Y. Wang,Luigi Naldini,John E. Dick,John E. Dick +44 more
TL;DR: Combined transcriptome and proteome analysis demonstrates that miR-126 targets the PI3K/AKT/MTOR signaling pathway, preserving LSC quiescence and promoting chemotherapy resistance.
Journal ArticleDOI
ID1 and ID3 regulate the self-renewal capacity of human colon cancer-initiating cells through p21.
Catherine A. O’Brien,Catherine A. O’Brien,Antonija Kreso,Antonija Kreso,Paul Ryan,Karin G. Hermans,Lianne Gibson,Yadong Wang,Andrew Tsatsanis,Steven Gallinger,Steven Gallinger,John E. Dick,John E. Dick +12 more
TL;DR: It is established that ID1 and ID3 function together to govern colon cancer-initiating cell (CC-IC) self-renewal through cell-cycle restriction driven by the cell- cycle inhibitor p21, linking tumor initiation function with chemotherapy resistance.
Journal ArticleDOI
Reduced Lymphoid Lineage Priming Promotes Human Hematopoietic Stem Cell Expansion
Peter van Galen,Antonija Kreso,Antonija Kreso,Erno Wienholds,Elisa Laurenti,Kolja Eppert,Eric R. Lechman,Nathan Mbong,Karin G. Hermans,Stephanie M. Dobson,Stephanie M. Dobson,Craig April,Jian-Bing Fan,John E. Dick,John E. Dick +14 more
TL;DR: Modulated expression levels of Inhibitor of DNA binding (ID) proteins were modulated to ask whether lineage priming affects self-renewal of human HSCs and found that lentiviral overexpression of ID proteins in cord blood H SCs biases myeloerythroid commitment at the expense of lymphoid differentiation.